2014
Graphical Modeling of Biological Pathways in Genome-wide Association Studies
Chen M, Cho J, Zhao H. Graphical Modeling of Biological Pathways in Genome-wide Association Studies. 2014, 294-317. DOI: 10.1093/acprof:oso/9780198709022.003.0012.Peer-Reviewed Original ResearchGenome-wide association studiesAssociation studiesAbstract Genome-wide association studiesBiological pathwaysDisease-associated genesPrior biological knowledgeNeighboring genesPathway topologyAssociation analysisBiological knowledgeGenesSpecific pathwaysPathwayCrohn's disease cohortDiscoveryExchangeable set
2011
Incorporating Biological Pathways via a Markov Random Field Model in Genome-Wide Association Studies
Chen M, Cho J, Zhao H. Incorporating Biological Pathways via a Markov Random Field Model in Genome-Wide Association Studies. PLOS Genetics 2011, 7: e1001353. PMID: 21490723, PMCID: PMC3072362, DOI: 10.1371/journal.pgen.1001353.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesAssociation studiesBiological pathwaysSingle gene-based methodsMarkov random field modelGene-based methodsPrior biological knowledgeRandom field modelGWAS analysisAssociation signalsMultiple genesPathway topologyGene associationsAssociation analysisGenesBiological knowledgeField modelGenetic variantsSpecific pathwaysReal data examplePathwayStatistical inferenceConditional modes algorithmExchangeable setRegression form