2023
Targeting ATAD3A-PINK1-mitophagy axis overcomes chemoimmunotherapy resistance by redirecting PD-L1 to mitochondria
Xie X, Yang Y, Wang Q, Liu H, Fang X, Li C, Jiang Y, Wang S, Zhao H, Miao J, Ding S, Liu X, Yao X, Yang W, Jiang J, Shao Z, Jin G, Bian X. Targeting ATAD3A-PINK1-mitophagy axis overcomes chemoimmunotherapy resistance by redirecting PD-L1 to mitochondria. Cell Research 2023, 33: 215-228. PMID: 36627348, PMCID: PMC9977947, DOI: 10.1038/s41422-022-00766-z.Peer-Reviewed Original ResearchConceptsImmune checkpoint inhibitorsPD-L1Combination therapyTherapeutic responsePD-1/PD-L1 signalingShorter progression-free survivalBreast cancer benefitProgression-free survivalPD-L1 signalingCheckpoint inhibitorsNab-paclitaxelCancer benefitImmunotherapy cohortImmune microenvironmentPreclinical resultsTumor cell membranesTumor samplesPaclitaxelHigh expressionPromising targetPatientsTherapyTumorsResistant factorATAD3A expression
2017
Metabolic Regulation of Gene Expression by Histone Lysine β‐hydroxybutyrylation
Zhang D, Xie Z, Chung D, Tang Z, Huang H, Dai L, Qi S, Li J, Colak G, Chen Y, Peng C, Ruan H, Wang D, Jensen L, Kwon O, Lee S, Pletcher S, Tan M, Lombard D, White K, Zhao H, Li J, Roeder R, Yang X, Zhao Y. Metabolic Regulation of Gene Expression by Histone Lysine β‐hydroxybutyrylation. The FASEB Journal 2017, 31 DOI: 10.1096/fasebj.31.1_supplement.755.2.Peer-Reviewed Original ResearchKetone bodiesNeuro-protective roleDiabetic ketoacidosisAdjunctive treatmentKetogenic dietBrain tumorsPharmacological effectsNeurodegenerative diseasesPathophysiological statesCultured cell linesMedical FoundationLines of evidenceCell linesEpilepsyΒ-hydroxybutyrylationNIHRNA-seq analysisMetabolic regulationRegulatory roleGene expressionShanghai Municipal ScienceMetabolic pathwaysKetoacidosisDiabetesPatients