A Powerful Approach to Estimating Annotation-Stratified Genetic Covariance via GWAS Summary Statistics
Lu Q, Li B, Ou D, Erlendsdottir M, Powles RL, Jiang T, Hu Y, Chang D, Jin C, Dai W, He Q, Liu Z, Mukherjee S, Crane PK, Zhao H. A Powerful Approach to Estimating Annotation-Stratified Genetic Covariance via GWAS Summary Statistics. American Journal Of Human Genetics 2017, 101: 939-964. PMID: 29220677, PMCID: PMC5812911, DOI: 10.1016/j.ajhg.2017.11.001.Peer-Reviewed Original ResearchConceptsGWAS summary statisticsGenome-wide association studiesComplex traitsSingle nucleotide polymorphismsGenetic covarianceGenetic architectureLarge-scale genome-wide association studiesStrong genetic covarianceDistinct genetic architecturesSignificant genetic covarianceLate-onset Alzheimer's diseaseHigh minor allele frequencyGenetic profileFunctional genomeAmyotrophic lateral sclerosisMajor neurodegenerative diseasesMinor allele frequencyGenetic basisAssociation studiesTraitsLarge-scale inferenceSummary statisticsBiological interpretabilityAllele frequenciesNeurodegenerative diseasesMetabolic Regulation of Gene Expression by Histone Lysine β‐hydroxybutyrylation
Zhang D, Xie Z, Chung D, Tang Z, Huang H, Dai L, Qi S, Li J, Colak G, Chen Y, Peng C, Ruan H, Wang D, Jensen L, Kwon O, Lee S, Pletcher S, Tan M, Lombard D, White K, Zhao H, Li J, Roeder R, Yang X, Zhao Y. Metabolic Regulation of Gene Expression by Histone Lysine β‐hydroxybutyrylation. The FASEB Journal 2017, 31 DOI: 10.1096/fasebj.31.1_supplement.755.2.Peer-Reviewed Original ResearchKetone bodiesNeuro-protective roleDiabetic ketoacidosisAdjunctive treatmentKetogenic dietBrain tumorsPharmacological effectsNeurodegenerative diseasesPathophysiological statesCultured cell linesMedical FoundationLines of evidenceCell linesEpilepsyΒ-hydroxybutyrylationNIHRNA-seq analysisMetabolic regulationRegulatory roleGene expressionShanghai Municipal ScienceMetabolic pathwaysKetoacidosisDiabetesPatients