2019
Initial Results From An Opioid Dependence Whole Exome Sequencing Study
Gelernter J, Sherva R, Zhao H, Kranzler H, Farrer L. Initial Results From An Opioid Dependence Whole Exome Sequencing Study. European Neuropsychopharmacology 2019, 29: s732. DOI: 10.1016/j.euroneuro.2017.06.056.Peer-Reviewed Original ResearchOpioid dependenceWhole-exome sequencesAfrican AmericansCase/control studySubstance use disordersSensory neuron developmentRisk markersPain perceptionSynaptic responsesWhole-exome sequencing studiesOD diagnosisUse disordersControl studySynaptic plasticityNeuron developmentExome sequencing studiesSynapse functionEuropean AmericansPrdm12Myotonic dystrophyGene-based testsBonferroni correctionCommon risk variantsOD riskRisk variants
2018
Translational studies support a role for serotonin 2B receptor (HTR2B) gene in aggression-related cannabis response
Montalvo-Ortiz JL, Zhou H, D’Andrea I, Maroteaux L, Lori A, Smith A, Ressler KJ, Nuñez YZ, Farrer LA, Zhao H, Kranzler HR, Gelernter J. Translational studies support a role for serotonin 2B receptor (HTR2B) gene in aggression-related cannabis response. Molecular Psychiatry 2018, 23: 2277-2286. PMID: 29875475, PMCID: PMC6281782, DOI: 10.1038/s41380-018-0077-6.Peer-Reviewed Original ResearchConceptsGrady Trauma ProjectAfrican AmericansWild-type miceReceptor geneEffects of cannabisWide significant risk lociResident-intruder paradigmImpulsivity/aggressionConcordant findingsTHC administrationKnockout miceTranslational studiesAA subjectsCannabis useStudy designTrauma ProjectAdverse effectsMiceCannabisAggressive behaviorEuropean AmericansNominal associationAdverse consequencesGenome-wide association study (GWAS) designRisk loci