2024
IL-1 receptor 1 signaling shapes the development of viral antigen-specific CD4+ T cell responses following COVID-19 mRNA vaccination
Park H, Shin M, Shin J, Kim H, Kang B, Par-Young J, Unlu S, Afinogenova Y, Catanzaro J, Young J, Kim M, Lee S, Jeon S, You S, Racke M, Bucala R, Kang I. IL-1 receptor 1 signaling shapes the development of viral antigen-specific CD4+ T cell responses following COVID-19 mRNA vaccination. EBioMedicine 2024, 103: 105114. PMID: 38640835, PMCID: PMC11041015, DOI: 10.1016/j.ebiom.2024.105114.Peer-Reviewed Original ResearchConceptsCD4<sup>+</sup> T cellsCOVID-19 mRNA vaccinesAntigen-specific CD4<sup>+</sup> T cell responsesT cell responsesPrimary antibody deficiencyCD4<sup>+</sup> T cell responsesT cellsIL-1R1MRNA vaccinesIL-1IgG antibodiesAntigen-specific CD4<sup>+</sup> T cellsCD4+ T cell responsesLevels of IL-1R1Human CD4<sup>+</sup> T cellsIL-1 receptor 1Healthy individualsDose of COVID-19 mRNA vaccineAntigen-specific CD4IL-1R1 expressionT cell immunityRepetitive antigenic stimulationCytokines interleukin (IL)-1Immune response to virusesExpression of IL-1R1
2023
VISTA (PD-1H) Is a Crucial Immune Regulator to Limit Pulmonary Fibrosis.
Kim S, Adams T, Hu Q, Shin H, Chae G, Lee S, Sharma L, Kwon H, Lee F, Park H, Huh W, Manning E, Kaminski N, Sauler M, Chen L, Song J, Kim T, Kang M. VISTA (PD-1H) Is a Crucial Immune Regulator to Limit Pulmonary Fibrosis. American Journal Of Respiratory Cell And Molecular Biology 2023, 69: 22-33. PMID: 36450109, PMCID: PMC10324045, DOI: 10.1165/rcmb.2022-0219oc.Peer-Reviewed Original ResearchConceptsIdiopathic pulmonary fibrosisPulmonary fibrosisImmune regulatorsTherapeutic potentialHuman idiopathic pulmonary fibrosisCrucial immune regulatorsNovel immune regulatorPulmonary fibrosis micePulmonary fibrosis modelNovel therapeutic targetRole of VISTAWild-type littermatesMonocyte-derived macrophagesT lymphocyte lineageVISTA expressionIPF treatmentAntibody treatmentImmune landscapeFibrotic mediatorsLung fibrosisFibrosis miceInflammatory responseFibrosis modelMyeloid populationsTherapeutic target
2022
AHCC®, a Standardized Extract of Cultured Lentinula Edodes Mycelia, Promotes the Anti-Tumor Effect of Dual Immune Checkpoint Blockade Effect in Murine Colon Cancer
Park HJ, Boo S, Park I, Shin MS, Takahashi T, Takanari J, Homma K, Kang I. AHCC®, a Standardized Extract of Cultured Lentinula Edodes Mycelia, Promotes the Anti-Tumor Effect of Dual Immune Checkpoint Blockade Effect in Murine Colon Cancer. Frontiers In Immunology 2022, 13: 875872. PMID: 35514996, PMCID: PMC9066372, DOI: 10.3389/fimmu.2022.875872.Peer-Reviewed Original ResearchConceptsDual immune checkpoint blockadeImmune checkpoint blockadeAnti-tumor effectsCheckpoint blockadeBearing miceStandardized extractTumor growthMC38 tumor-bearing miceGut microbiomePD-1/CTLATumor-infiltrating CD8Cell functionCancer bearing miceT cell functionKi-67 expressionImmune cell functionMurine colon cancerTumor bearing miceTumor-bearing miceTreatment of cancerTreatment strategiesT cellsTherapeutic effectGranzyme BColon cancer
2021
Nucleotide‐binding domain and leucine‐rich‐repeat‐containing protein X1 deficiency induces nicotinamide adenine dinucleotide decline, mechanistic target of rapamycin activation, and cellular senescence and accelerates aging lung‐like changes
Shin HJ, Kim S, Park H, Shin M, Kang I, Kang M. Nucleotide‐binding domain and leucine‐rich‐repeat‐containing protein X1 deficiency induces nicotinamide adenine dinucleotide decline, mechanistic target of rapamycin activation, and cellular senescence and accelerates aging lung‐like changes. Aging Cell 2021, 20: e13410. PMID: 34087956, PMCID: PMC8282248, DOI: 10.1111/acel.13410.Peer-Reviewed Original ResearchConceptsCellular senescenceActivation of mTORNucleotide-binding domainCellular senescence responseReplicative cellular senescenceNLR family membersOrganismal agingCellular physiologyMitochondrial moleculesSenescence responseCellular locationProtein X1Crucial regulatorMechanistic targetMitochondrial functionMolecular hallmarksNLRX1 functionRapamycin (mTOR) activationMitochondrial dysfunctionSenescenceMTORPharmacological inhibitionNLRX1BiologyAging LungCo-inhibitor expression on tumor infiltrating and splenic lymphocytes after dual checkpoint inhibition in a microsatellite stable model of colorectal cancer
Slovak RJ, Park HJ, Kamp WM, Ludwig JM, Kang I, Kim HS. Co-inhibitor expression on tumor infiltrating and splenic lymphocytes after dual checkpoint inhibition in a microsatellite stable model of colorectal cancer. Scientific Reports 2021, 11: 6956. PMID: 33772035, PMCID: PMC7997991, DOI: 10.1038/s41598-021-85810-5.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, CDCD4-Positive T-LymphocytesCell Line, TumorCell ProliferationColorectal NeoplasmsCTLA-4 AntigenFemaleHepatitis A Virus Cellular Receptor 2Immune Checkpoint InhibitorsLymphocyte Activation Gene 3 ProteinLymphocytes, Tumor-InfiltratingMaleMiceMice, Inbred BALB CMicrosatellite RepeatsProgrammed Cell Death 1 ReceptorSpleenT-Lymphocytes, CytotoxicConceptsDual checkpoint inhibitionPD-1 inhibitionColorectal cancerCheckpoint inhibitionPD-1Checkpoint inhibitorsT cellsImmune responseRobust anti-tumor immune responseAnti-PD-1 groupAnti-PD-1 antibodyAnti-tumor immune responseMicrosatellite stable colorectal cancerDual PD-1Majority of patientsDeficient mismatch repairStable colorectal cancerCTLA-4 inhibitionTumor growth rateHigh microsatellite instabilityPotential escape mechanismsCombination immunotherapyImmunosuppressive checkpointsTumoral infiltrationDual therapy
2019
Estrogen receptor α in T cells suppresses follicular helper T cell responses and prevents autoimmunity
Kim D, Park H, Park H, Lee J, Ko C, Gye M, Choi J. Estrogen receptor α in T cells suppresses follicular helper T cell responses and prevents autoimmunity. Experimental & Molecular Medicine 2019, 51: 1-9. PMID: 30988419, PMCID: PMC6465332, DOI: 10.1038/s12276-019-0237-z.Peer-Reviewed Original ResearchConceptsSheep red blood cellsKO miceT cellsTfh cellsTfh responsesAutoantibody productionFollicular helper T cell responsesHigh-affinity antigen-specific antibodiesCell responsesFollicular helper T cellsHelper T cell responsesERα KO miceTfh cell responsesMesenteric lymph nodesT cell responsesHelper T cellsGerminal center responseERα knockout miceWild-type miceAntigen-specific antibodiesYears of ageEstrogen receptor alphaEstrogen receptor αIsotype class switchingTreg cells
2018
Regulation of chitinase-3-like-1 in T cell elicits Th1 and cytotoxic responses to inhibit lung metastasis
Kim DH, Park HJ, Lim S, Koo JH, Lee HG, Choi JO, Oh JH, Ha SJ, Kang MJ, Lee CM, Lee CG, Elias JA, Choi JM. Regulation of chitinase-3-like-1 in T cell elicits Th1 and cytotoxic responses to inhibit lung metastasis. Nature Communications 2018, 9: 503. PMID: 29403003, PMCID: PMC5799380, DOI: 10.1038/s41467-017-02731-6.Peer-Reviewed Original ResearchConceptsT cellsLung metastasesTh1 cellsCHI3L1 expressionFunction of CHI3L1Type 2 inflammationAnti-tumor immunityMelanoma lung metastasisActivated T cellsElicit Th1CTL responsesEnhanced Th1Th2 cellsTherapeutic targetClinical implicationsCytotoxic responseTh1MetastasisTCR stimulationCHI3L1Peptide-siRNA complexLungCellsNegative regulatorImmunity genes
2017
Sex-specific regulation of immune responses by PPARs
Park H, Choi J. Sex-specific regulation of immune responses by PPARs. Experimental & Molecular Medicine 2017, 49: e364-e364. PMID: 28775365, PMCID: PMC5579504, DOI: 10.1038/emm.2017.102.Peer-Reviewed Original ResearchConceptsImmune responseT cellsEffector T cell responsesPeroxisome proliferator-activated receptor ligandsSex-specific immune responsesExperimental autoimmune encephalomyelitisEffector T cellsT cell responsesRole of PPART cell activationHost diseaseAutoimmune encephalomyelitisAutoimmune diseasesSex hormonesForeign antigensSex-specific differencesKnockout miceMetabolic diseasesImmune systemPPARReceptor ligandsInhibitory functionDiseaseSex-specific regulationSex differences
2016
Sex-Based Selectivity of PPARγ Regulation in Th1, Th2, and Th17 Differentiation
Park HJ, Park HS, Lee JU, Bothwell AL, Choi JM. Sex-Based Selectivity of PPARγ Regulation in Th1, Th2, and Th17 Differentiation. International Journal Of Molecular Sciences 2016, 17: 1347. PMID: 27548145, PMCID: PMC5000743, DOI: 10.3390/ijms17081347.Peer-Reviewed Original ResearchConceptsEffector T cell differentiationT cellsT cell differentiationAdaptive immunityFemale T cellsMale T cellsPeroxisome proliferator-activated receptor gammaIL-17 productionDifferentiation of Th1PPARγ agonist pioglitazoneProliferator-activated receptor gammaNaïve T cellsSplenic T cellsMouse splenic T cellsImportant immune regulatorPioglitazone treatmentTfh responsesTh17 cellsAgonist pioglitazoneTreg functionAutoimmune diseasesEstrogen exposureImmune regulatorsCell differentiationTh1Gender-specific differences in PPARγ regulation of follicular helper T cell responses with estrogen
Park HJ, Park HS, Lee JU, Bothwell AL, Choi JM. Gender-specific differences in PPARγ regulation of follicular helper T cell responses with estrogen. Scientific Reports 2016, 6: 28495. PMID: 27335315, PMCID: PMC4917844, DOI: 10.1038/srep28495.Peer-Reviewed Original ResearchConceptsFollicular helper T cell responsesHelper T cell responsesT cell responsesCell responsesTfh cellsT cellsGC responseMale T cellsPeroxisome proliferator-activated receptor gammaTfh cell responsesEffector T cellsPPARγ agonist pioglitazoneProliferator-activated receptor gammaT cell regulationWild-type miceRole of PPARγGerminal center B cellsT cell activationGender-specific differencesTfh responsesAgonist pioglitazoneAutoimmune diseasesMenstrual cycleFemale miceMale mice
2015
dNP2 is a blood–brain barrier-permeable peptide enabling ctCTLA-4 protein delivery to ameliorate experimental autoimmune encephalomyelitis
Lim S, Kim WJ, Kim YH, Lee S, Koo JH, Lee JA, Yoon H, Kim DH, Park HJ, Kim HM, Lee HG, Yun Kim J, Lee JU, Hun Shin J, Kyun Kim L, Doh J, Kim H, Lee SK, Bothwell AL, Suh M, Choi JM. dNP2 is a blood–brain barrier-permeable peptide enabling ctCTLA-4 protein delivery to ameliorate experimental autoimmune encephalomyelitis. Nature Communications 2015, 6: 8244. PMID: 26372309, PMCID: PMC4579786, DOI: 10.1038/ncomms9244.Peer-Reviewed Original ResearchConceptsExperimental autoimmune encephalomyelitisMultiple sclerosisT cellsAutoimmune encephalomyelitisCytotoxic T-lymphocyte antigen-4T-lymphocyte antigen-4T helper 17 (Th17) cellsCNS inflammatory diseasesTherapeutic mouse modelsEffector T cellsHelper 17 cellsT helper 1Blood-brain barrierCentral nervous systemHuman T cellsHelper 1Antigen-4Inflammatory diseasesMouse modelNervous systemCurrent drugsResident cellsBrain tissueEffective agentCell-permeable peptide
2014
Cell membrane penetrating function of the nuclear localization sequence in human cytokine IL-1α
Koo J, Yoon H, Kim W, Lim S, Park H, Choi J. Cell membrane penetrating function of the nuclear localization sequence in human cytokine IL-1α. Molecular Biology Reports 2014, 41: 8117-8126. PMID: 25205122, DOI: 10.1007/s11033-014-3711-7.Peer-Reviewed Original ResearchConceptsNuclear localization sequenceLocalization sequenceCell penetrating peptideSpecific gene expressionCell membraneEnhanced green fluorescence proteinGreen fluorescence proteinHeparan sulfate interactionProtein delivery efficiencyMembrane penetration abilityGene expressionTAT-CPPFluorescence proteinCellular responsesPrecursor formAmino acidsIntracellular delivery efficiencyProteinDelivery peptidePenetrating peptideSequenceSulfate interactionInterleukin-1 alphaMembraneCellsPPARγ Negatively Regulates T Cell Activation to Prevent Follicular Helper T Cells and Germinal Center Formation
Park HJ, Kim DH, Choi JY, Kim WJ, Kim JY, Senejani AG, Hwang SS, Kim LK, Tobiasova Z, Lee GR, Craft J, Bothwell AL, Choi JM. PPARγ Negatively Regulates T Cell Activation to Prevent Follicular Helper T Cells and Germinal Center Formation. PLOS ONE 2014, 9: e99127. PMID: 24921943, PMCID: PMC4055678, DOI: 10.1371/journal.pone.0099127.Peer-Reviewed Original ResearchConceptsFollicular helper T cellsHelper T cellsT cellsGerminal center reactionTfh cellsSheep red blood cell immunizationRed blood cell immunizationCenter reactionPeroxisome proliferator-activated receptor gammaIL-21 expressionProliferator-activated receptor gammaWild-type T cellsType T cellsGerminal center formationGerminal center B cellsT cell activationCell immunizationAutoantibody productionGlomerular inflammationSignature cytokinesAdaptive immunityGerminal centersGlucose metabolismNF-κBB cells
2010
TLR4-mediated activation of mouse macrophages by Korean mistletoe lectin-C (KML-C)
Park H, Hong J, Kwon H, Kim Y, Lee K, Kim J, Song S. TLR4-mediated activation of mouse macrophages by Korean mistletoe lectin-C (KML-C). Biochemical And Biophysical Research Communications 2010, 396: 721-725. PMID: 20450885, DOI: 10.1016/j.bbrc.2010.04.169.Peer-Reviewed Original ResearchConceptsInterleukin-1 receptor-associated kinase 1TNF-alpha productionKorean mistletoe lectinTNF-alphaTLR4 moleculesMouse macrophagesReceptor-associated kinase 1Mucosal immune cellsTNF-alpha secretionMistletoe lectinMouse peritoneal macrophagesImmune cellsMacrophage activationTLR4Immunomodulatory activityPeritoneal macrophagesMacrophagesCancer cellsUnderlying mechanismKinase 1ActivationDownstream eventsCellsCytokinesAdjuvant