2018
Regulation of chitinase-3-like-1 in T cell elicits Th1 and cytotoxic responses to inhibit lung metastasis
Kim DH, Park HJ, Lim S, Koo JH, Lee HG, Choi JO, Oh JH, Ha SJ, Kang MJ, Lee CM, Lee CG, Elias JA, Choi JM. Regulation of chitinase-3-like-1 in T cell elicits Th1 and cytotoxic responses to inhibit lung metastasis. Nature Communications 2018, 9: 503. PMID: 29403003, PMCID: PMC5799380, DOI: 10.1038/s41467-017-02731-6.Peer-Reviewed Original ResearchConceptsT cellsLung metastasesTh1 cellsCHI3L1 expressionFunction of CHI3L1Type 2 inflammationAnti-tumor immunityMelanoma lung metastasisActivated T cellsElicit Th1CTL responsesEnhanced Th1Th2 cellsTherapeutic targetClinical implicationsCytotoxic responseTh1MetastasisTCR stimulationCHI3L1Peptide-siRNA complexLungCellsNegative regulatorImmunity genes
2015
PPARγ controls effector T cell functions to prevent autoimmunity in gender different way (BA4P.135)
Park H, Kim D, Kim W, Choi J. PPARγ controls effector T cell functions to prevent autoimmunity in gender different way (BA4P.135). The Journal Of Immunology 2015, 194: 47.15-47.15. DOI: 10.4049/jimmunol.194.supp.47.15.Peer-Reviewed Original ResearchT cell functionT cellsPeroxisome proliferator-activated receptor gammaTh17 cellsEstrogen receptorEffector T cell functionFollicular helper T cellsHelper T cellsAuto-antibody productionExpression of Bcl-2T cell differentiationProliferator-activated receptor gammaMild autoimmune phenotypeIL-7RAPrevent autoimmunityPioglitazone treatmentGerminal centersMale miceTCR stimulationAdaptive immunityAutoimmune phenotypeDecreased expressionBcl-2MiceMouse phenotype