2020
Defining heterogeneity and biological signature in human effector memory CD8+ T cells expressing different levels of IL-7 receptor alpha by high-dimensional analysis
Shin M, Kim D, Park H, Dong X, Koumpouras F, Kang I. Defining heterogeneity and biological signature in human effector memory CD8+ T cells expressing different levels of IL-7 receptor alpha by high-dimensional analysis. The Journal Of Immunology 2020, 204: 154.19-154.19. DOI: 10.4049/jimmunol.204.supp.154.19.Peer-Reviewed Original ResearchHuman effector memory CD8EM CD8Effector memory CD8T cellsIL-7RαMemory CD8Cell subsetsIL-7 receptor alphaIL-7 receptor alpha chainT cell subsetsCo-stimulatory moleculesT cell heterogeneityHigh-dimensional single-cell analysisReceptor alpha chainLupus patientsImmune landscapeCell surface moleculesHeterogeneous cell subsetsT-betCD8Effector functionsDifferential expressionReceptor alphaSingle-cell RNA-seq analysisPathologic conditions
2015
Chitinase like protein BRP-39 suppress Th1 differentiation via regulation of IFNγ-STAT1 axis (LYM8P.633)
Kim D, Park H, Lee J, Kang M, Lee C, Elias J, Choi J. Chitinase like protein BRP-39 suppress Th1 differentiation via regulation of IFNγ-STAT1 axis (LYM8P.633). The Journal Of Immunology 2015, 194: 201.9-201.9. DOI: 10.4049/jimmunol.194.supp.201.9.Peer-Reviewed Original ResearchT cell immunityBRP-39Th1 cellsT cellsTCR stimuliUp-regulate T-betExpression of PTPN2Naive CD4 T cellsIncreased production of IL-2Production of IL-2CD4 T cellsNaive T cellsT cell activationEnzyme sitesChitinase activityParasite life cycleAnti-parasite immune responsesSignaling pathwayRegulatory roleChitinaseTh2 cellsInnate immunityT-betTh1 differentiationIFN-g
2013
Germinal Center Formation Controlled by Balancing Between Follicular Helper T Cells and Follicular Regulatory T Cells
Park H, Kim D, Choi J. Germinal Center Formation Controlled by Balancing Between Follicular Helper T Cells and Follicular Regulatory T Cells. Hanyang Medical Reviews 2013, 33: 10-16. DOI: 10.7599/hmr.2013.33.1.10.Peer-Reviewed Original ResearchFollicular helper T cellsFollicular regulatory T cellsGerminal center reactionRegulatory T cellsHelper T cellsT cell helpT cellsB cellsCenter reactionAutoimmune diseasesCell helpT-betBCL-6Antigen-specific T cellsTranscription factor Bcl-6Expression of CXCR5B cell folliclesPeripheral tolerance mechanismsCD4 T cellsMemory B cellsGerminal center formationIsotype class switchingTfh populationTh17 cellsTfh differentiation