2016
Sex-Based Selectivity of PPARγ Regulation in Th1, Th2, and Th17 Differentiation
Park HJ, Park HS, Lee JU, Bothwell AL, Choi JM. Sex-Based Selectivity of PPARγ Regulation in Th1, Th2, and Th17 Differentiation. International Journal Of Molecular Sciences 2016, 17: 1347. PMID: 27548145, PMCID: PMC5000743, DOI: 10.3390/ijms17081347.Peer-Reviewed Original ResearchConceptsEffector T cell differentiationT cellsT cell differentiationAdaptive immunityFemale T cellsMale T cellsPeroxisome proliferator-activated receptor gammaIL-17 productionDifferentiation of Th1PPARγ agonist pioglitazoneProliferator-activated receptor gammaNaïve T cellsSplenic T cellsMouse splenic T cellsImportant immune regulatorPioglitazone treatmentTfh responsesTh17 cellsAgonist pioglitazoneTreg functionAutoimmune diseasesEstrogen exposureImmune regulatorsCell differentiationTh1
2015
PPARγ controls effector T cell functions to prevent autoimmunity in gender different way (BA4P.135)
Park H, Kim D, Kim W, Choi J. PPARγ controls effector T cell functions to prevent autoimmunity in gender different way (BA4P.135). The Journal Of Immunology 2015, 194: 47.15-47.15. DOI: 10.4049/jimmunol.194.supp.47.15.Peer-Reviewed Original ResearchT cell functionT cellsPeroxisome proliferator-activated receptor gammaTh17 cellsEstrogen receptorEffector T cell functionFollicular helper T cellsHelper T cellsAuto-antibody productionExpression of Bcl-2T cell differentiationProliferator-activated receptor gammaMild autoimmune phenotypeIL-7RAPrevent autoimmunityPioglitazone treatmentGerminal centersMale miceTCR stimulationAdaptive immunityAutoimmune phenotypeDecreased expressionBcl-2MiceMouse phenotype