2019
Estrogen receptor α in T cells suppresses follicular helper T cell responses and prevents autoimmunity
Kim D, Park H, Park H, Lee J, Ko C, Gye M, Choi J. Estrogen receptor α in T cells suppresses follicular helper T cell responses and prevents autoimmunity. Experimental & Molecular Medicine 2019, 51: 1-9. PMID: 30988419, PMCID: PMC6465332, DOI: 10.1038/s12276-019-0237-z.Peer-Reviewed Original ResearchConceptsSheep red blood cellsKO miceT cellsTfh cellsTfh responsesAutoantibody productionFollicular helper T cell responsesHigh-affinity antigen-specific antibodiesCell responsesFollicular helper T cellsHelper T cell responsesERα KO miceTfh cell responsesMesenteric lymph nodesT cell responsesHelper T cellsGerminal center responseERα knockout miceWild-type miceAntigen-specific antibodiesYears of ageEstrogen receptor alphaEstrogen receptor αIsotype class switchingTreg cells
2015
PPARγ controls effector T cell functions to prevent autoimmunity in gender different way (BA4P.135)
Park H, Kim D, Kim W, Choi J. PPARγ controls effector T cell functions to prevent autoimmunity in gender different way (BA4P.135). The Journal Of Immunology 2015, 194: 47.15-47.15. DOI: 10.4049/jimmunol.194.supp.47.15.Peer-Reviewed Original ResearchT cell functionT cellsPeroxisome proliferator-activated receptor gammaTh17 cellsEstrogen receptorEffector T cell functionFollicular helper T cellsHelper T cellsAuto-antibody productionExpression of Bcl-2T cell differentiationProliferator-activated receptor gammaMild autoimmune phenotypeIL-7RAPrevent autoimmunityPioglitazone treatmentGerminal centersMale miceTCR stimulationAdaptive immunityAutoimmune phenotypeDecreased expressionBcl-2MiceMouse phenotype
2014
PPARγ Negatively Regulates T Cell Activation to Prevent Follicular Helper T Cells and Germinal Center Formation
Park HJ, Kim DH, Choi JY, Kim WJ, Kim JY, Senejani AG, Hwang SS, Kim LK, Tobiasova Z, Lee GR, Craft J, Bothwell AL, Choi JM. PPARγ Negatively Regulates T Cell Activation to Prevent Follicular Helper T Cells and Germinal Center Formation. PLOS ONE 2014, 9: e99127. PMID: 24921943, PMCID: PMC4055678, DOI: 10.1371/journal.pone.0099127.Peer-Reviewed Original ResearchConceptsFollicular helper T cellsHelper T cellsT cellsGerminal center reactionTfh cellsSheep red blood cell immunizationRed blood cell immunizationCenter reactionPeroxisome proliferator-activated receptor gammaIL-21 expressionProliferator-activated receptor gammaWild-type T cellsType T cellsGerminal center formationGerminal center B cellsT cell activationCell immunizationAutoantibody productionGlomerular inflammationSignature cytokinesAdaptive immunityGerminal centersGlucose metabolismNF-κBB cellsInsights into the Role of Follicular Helper T Cells in Autoimmunity
Park H, Kim D, Lim S, Kim W, Youn J, Choi Y, Choi J. Insights into the Role of Follicular Helper T Cells in Autoimmunity. Immune Network 2014, 14: 21-29. PMID: 24605077, PMCID: PMC3942504, DOI: 10.4110/in.2014.14.1.21.Peer-Reviewed Original ResearchTfh cell differentiationFollicular helper T cellsTfh cellsSystemic lupus erythematosusHelper T cellsT cellsAutoimmune diseasesB cellsBcl-6 expressionRheumatoid arthritisGerminal centersBCL-6Follicular regulatory T cellsB cell folliclesRegulatory T cellsNaïve T cellsMemory B cellsSurface moleculesCell differentiationImportant surface moleculesTfr cellsTreg cellsIL-21Lupus erythematosusPD-1
2013
The nuclear receptor PPARγ regulates T cell tolerance and germinal center formation via generation of follicular helper T cells (P4545)
Choi J, Park H, Choi J, Senejani A, Tobiasova Z, Kim D, Bothwell A. The nuclear receptor PPARγ regulates T cell tolerance and germinal center formation via generation of follicular helper T cells (P4545). The Journal Of Immunology 2013, 190: 197.7-197.7. DOI: 10.4049/jimmunol.190.supp.197.7.Peer-Reviewed Original ResearchT cell toleranceFollicular helper T cellsHelper T cellsT cellsGerminal center formationDeficient T cellsCell toleranceHelper T cell subsetsExpression of IkBαPeroxisome proliferator-activated receptor gammaT cell subsetsProliferator-activated receptor gammaWild-type T cellsType T cellsRole of PPARγNuclear receptor PPARγFunction of PPARγPhosphorylation of ERKTfh generationTh9 cellsIL-17Kidney inflammationAutoantibody productionCell subsetsCenter formationGerminal Center Formation Controlled by Balancing Between Follicular Helper T Cells and Follicular Regulatory T Cells
Park H, Kim D, Choi J. Germinal Center Formation Controlled by Balancing Between Follicular Helper T Cells and Follicular Regulatory T Cells. Hanyang Medical Reviews 2013, 33: 10-16. DOI: 10.7599/hmr.2013.33.1.10.Peer-Reviewed Original ResearchFollicular helper T cellsFollicular regulatory T cellsGerminal center reactionRegulatory T cellsHelper T cellsT cell helpT cellsB cellsCenter reactionAutoimmune diseasesCell helpT-betBCL-6Antigen-specific T cellsTranscription factor Bcl-6Expression of CXCR5B cell folliclesPeripheral tolerance mechanismsCD4 T cellsMemory B cellsGerminal center formationIsotype class switchingTfh populationTh17 cellsTfh differentiation