2014
PPARγ Negatively Regulates T Cell Activation to Prevent Follicular Helper T Cells and Germinal Center Formation
Park HJ, Kim DH, Choi JY, Kim WJ, Kim JY, Senejani AG, Hwang SS, Kim LK, Tobiasova Z, Lee GR, Craft J, Bothwell AL, Choi JM. PPARγ Negatively Regulates T Cell Activation to Prevent Follicular Helper T Cells and Germinal Center Formation. PLOS ONE 2014, 9: e99127. PMID: 24921943, PMCID: PMC4055678, DOI: 10.1371/journal.pone.0099127.Peer-Reviewed Original ResearchConceptsFollicular helper T cellsHelper T cellsT cellsGerminal center reactionTfh cellsSheep red blood cell immunizationRed blood cell immunizationCenter reactionPeroxisome proliferator-activated receptor gammaIL-21 expressionProliferator-activated receptor gammaWild-type T cellsType T cellsGerminal center formationGerminal center B cellsT cell activationCell immunizationAutoantibody productionGlomerular inflammationSignature cytokinesAdaptive immunityGerminal centersGlucose metabolismNF-κBB cells
2013
Germinal Center Formation Controlled by Balancing Between Follicular Helper T Cells and Follicular Regulatory T Cells
Park H, Kim D, Choi J. Germinal Center Formation Controlled by Balancing Between Follicular Helper T Cells and Follicular Regulatory T Cells. Hanyang Medical Reviews 2013, 33: 10-16. DOI: 10.7599/hmr.2013.33.1.10.Peer-Reviewed Original ResearchFollicular helper T cellsFollicular regulatory T cellsGerminal center reactionRegulatory T cellsHelper T cellsT cell helpT cellsB cellsCenter reactionAutoimmune diseasesCell helpT-betBCL-6Antigen-specific T cellsTranscription factor Bcl-6Expression of CXCR5B cell folliclesPeripheral tolerance mechanismsCD4 T cellsMemory B cellsGerminal center formationIsotype class switchingTfh populationTh17 cellsTfh differentiation