2022
T cell response to influenza vaccination remains intact in adults with congenital heart disease who underwent early thymectomy
Leone DM, Park HJ, Unlu S, Gurvitz M, Kang I, Elder RW. T cell response to influenza vaccination remains intact in adults with congenital heart disease who underwent early thymectomy. International Journal Of Cardiology Congenital Heart Disease 2022, 8: 100359. PMID: 35600131, PMCID: PMC9122016, DOI: 10.1016/j.ijcchd.2022.100359.Peer-Reviewed Original ResearchT cell responsesCongenital heart diseaseT cellsInfluenza vaccinationEarly thymectomyMemory CD4Heart diseaseAdequate T-cell responsesCell responsesT cell distributionT cell subsetsNaïve T cellsCongenital heart surgeryYears of ageHemagglutination inhibition assaysRoutine vaccinationVaccine immunityCell subsetsMean ageHeart surgeryNaïve CD4Healthy controlsThymectomyBlood samplesDiminished response
2019
Estrogen receptor α in T cells suppresses follicular helper T cell responses and prevents autoimmunity
Kim D, Park H, Park H, Lee J, Ko C, Gye M, Choi J. Estrogen receptor α in T cells suppresses follicular helper T cell responses and prevents autoimmunity. Experimental & Molecular Medicine 2019, 51: 1-9. PMID: 30988419, PMCID: PMC6465332, DOI: 10.1038/s12276-019-0237-z.Peer-Reviewed Original ResearchConceptsSheep red blood cellsKO miceT cellsTfh cellsTfh responsesAutoantibody productionFollicular helper T cell responsesHigh-affinity antigen-specific antibodiesCell responsesFollicular helper T cellsHelper T cell responsesERα KO miceTfh cell responsesMesenteric lymph nodesT cell responsesHelper T cellsGerminal center responseERα knockout miceWild-type miceAntigen-specific antibodiesYears of ageEstrogen receptor alphaEstrogen receptor αIsotype class switchingTreg cells
2016
Gender-specific differences in PPARγ regulation of follicular helper T cell responses with estrogen
Park HJ, Park HS, Lee JU, Bothwell AL, Choi JM. Gender-specific differences in PPARγ regulation of follicular helper T cell responses with estrogen. Scientific Reports 2016, 6: 28495. PMID: 27335315, PMCID: PMC4917844, DOI: 10.1038/srep28495.Peer-Reviewed Original ResearchConceptsFollicular helper T cell responsesHelper T cell responsesT cell responsesCell responsesTfh cellsT cellsGC responseMale T cellsPeroxisome proliferator-activated receptor gammaTfh cell responsesEffector T cellsPPARγ agonist pioglitazoneProliferator-activated receptor gammaT cell regulationWild-type miceRole of PPARγGerminal center B cellsT cell activationGender-specific differencesTfh responsesAgonist pioglitazoneAutoimmune diseasesMenstrual cycleFemale miceMale mice