2015
Chitinase like protein BRP-39 suppress Th1 differentiation via regulation of IFNγ-STAT1 axis (LYM8P.633)
Kim D, Park H, Lee J, Kang M, Lee C, Elias J, Choi J. Chitinase like protein BRP-39 suppress Th1 differentiation via regulation of IFNγ-STAT1 axis (LYM8P.633). The Journal Of Immunology 2015, 194: 201.9-201.9. DOI: 10.4049/jimmunol.194.supp.201.9.Peer-Reviewed Original ResearchT cell immunityBRP-39Th1 cellsT cellsTCR stimuliUp-regulate T-betExpression of PTPN2Naive CD4 T cellsIncreased production of IL-2Production of IL-2CD4 T cellsNaive T cellsT cell activationEnzyme sitesChitinase activityParasite life cycleAnti-parasite immune responsesSignaling pathwayRegulatory roleChitinaseTh2 cellsInnate immunityT-betTh1 differentiationIFN-gPiceatannol inhibits effector T cell functions by suppressing TcR signaling
Kim D, Lee Y, Park H, Lee J, Kim H, Hwang J, Choi J. Piceatannol inhibits effector T cell functions by suppressing TcR signaling. International Immunopharmacology 2015, 25: 285-292. PMID: 25676533, DOI: 10.1016/j.intimp.2015.01.030.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, CDAntigens, Differentiation, T-LymphocyteCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell DifferentiationCytokinesFemaleInterleukin-2 Receptor alpha SubunitLectins, C-TypeMice, Inbred C57BLMitogen-Activated Protein KinasesPhosphorylationProtein Kinase InhibitorsReceptors, Antigen, T-CellSpleenStilbenesConceptsEffector T cell functionT cell functionT cellsPiceatannol treatmentT cell activation markers CD25Naïve CD4 T cellsRole of piceatannolCD4 T cellsActivation markers CD25Cell functionAdaptive immune responsesSplenic T cellsMetabolite of resveratrolMurine splenic T cellsInhibition of TCRActivated T cellsAnti-tumorigenesis activityT cell activationIL-17Th17 cellsCytokines IFNγC57BL/6 miceCytokine productionIL-2Immune response
2013
Germinal Center Formation Controlled by Balancing Between Follicular Helper T Cells and Follicular Regulatory T Cells
Park H, Kim D, Choi J. Germinal Center Formation Controlled by Balancing Between Follicular Helper T Cells and Follicular Regulatory T Cells. Hanyang Medical Reviews 2013, 33: 10-16. DOI: 10.7599/hmr.2013.33.1.10.Peer-Reviewed Original ResearchFollicular helper T cellsFollicular regulatory T cellsGerminal center reactionRegulatory T cellsHelper T cellsT cell helpT cellsB cellsCenter reactionAutoimmune diseasesCell helpT-betBCL-6Antigen-specific T cellsTranscription factor Bcl-6Expression of CXCR5B cell folliclesPeripheral tolerance mechanismsCD4 T cellsMemory B cellsGerminal center formationIsotype class switchingTfh populationTh17 cellsTfh differentiation