2017
A deafness mechanism of digenic Cx26 (GJB2) and Cx30 (GJB6) mutations: Reduction of endocochlear potential by impairment of heterogeneous gap junctional function in the cochlear lateral wall
Mei L, Chen J, Zong L, Zhu Y, Liang C, Jones R, Zhao H. A deafness mechanism of digenic Cx26 (GJB2) and Cx30 (GJB6) mutations: Reduction of endocochlear potential by impairment of heterogeneous gap junctional function in the cochlear lateral wall. Neurobiology Of Disease 2017, 108: 195-203. PMID: 28823936, PMCID: PMC5675824, DOI: 10.1016/j.nbd.2017.08.002.Peer-Reviewed Original ResearchConceptsCochlear lateral wallEndocochlear potentialHearing lossGap junctional functionDeafness mechanismLateral wallHeterozygous miceCx30 mutationsHair cell degenerationHomozygous knockout miceJunctional functionHeterozygous mouse modelGap junctionsOrgan of CortiSame gap junctional plaquesEP reductionFrequent causePathological changesMouse modelKnockout miceReceptor currentsCell degenerationNormal hearingHeterozygous mutationsMice
2014
Connexin26 (GJB2) deficiency reduces active cochlear amplification leading to late-onset hearing loss
Zhu Y, Chen J, Liang C, Zong L, Chen J, Jones R, Zhao H. Connexin26 (GJB2) deficiency reduces active cochlear amplification leading to late-onset hearing loss. Neuroscience 2014, 284: 719-729. PMID: 25451287, PMCID: PMC4268423, DOI: 10.1016/j.neuroscience.2014.10.061.Peer-Reviewed Original ResearchConceptsLate-onset hearing lossActive cochlear amplificationDistortion product otoacoustic emissionsHearing lossNonsyndromic hearing lossTherapeutic interventionsProgressive hearing lossHair cell lossPostnatal day 5Cochlear amplificationProduct otoacoustic emissionsConditional knockout miceKnockout miceClinical observationsDay 5Cell lossEndocochlear potentialOtoacoustic emissionsNormal hearingCx26 expressionDeafness mechanismMiceCx26 deficiencyCochleaIntervention
2008
Cellular characterization of Connexin26 and Connnexin30 expression in the cochlear lateral wall
Liu Y, Zhao H. Cellular characterization of Connexin26 and Connnexin30 expression in the cochlear lateral wall. Cell And Tissue Research 2008, 333: 395. PMID: 18581144, PMCID: PMC2548271, DOI: 10.1007/s00441-008-0641-5.Peer-Reviewed Original Research
2001
Long-term natural culture of cochlear sensory epithelia of guinea pigs
Zhao H. Long-term natural culture of cochlear sensory epithelia of guinea pigs. Neuroscience Letters 2001, 315: 73-76. PMID: 11711218, DOI: 10.1016/s0304-3940(01)02357-6.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCells, CulturedCochleaEpithelial CellsFluorescent Antibody TechniqueGuinea PigsMicroscopy, Phase-ContrastTimeConceptsCochlear sensory epitheliumCochlear sensory epithelial cellsSensory epithelial cellsSensory epitheliumHair cell markersCochlear cell lineIsolated cell clonesCochlear cellsEpithelial morphotypeGenetic manipulationProtein ZO-1Genetic studiesValuable cell sourceCulture cellsGuinea pigsCell linesEpithelial cellsZO-1Tight junctionsCell markersNatural cultureCell sourceCellsCell clonesCulture medium