2013
Active cochlear amplification is dependent on supporting cell gap junctions
Zhu Y, Liang C, Chen J, Zong L, Chen G, Zhao H. Active cochlear amplification is dependent on supporting cell gap junctions. Nature Communications 2013, 4: 1786. PMID: 23653198, PMCID: PMC3675877, DOI: 10.1038/ncomms2806.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAuditory ThresholdCochlear Microphonic PotentialsConnexin 26ConnexinsEvoked Potentials, Auditory, Brain StemGap JunctionsGene DeletionGene TargetingHair Cells, Auditory, OuterHearing LossLabyrinth Supporting CellsMiceMice, KnockoutMolecular Motor ProteinsNonlinear DynamicsOtoacoustic Emissions, SpontaneousSpiral GanglionConceptsActive cochlear amplificationOuter hair cellsCell gap junctionsHearing lossCochlear amplificationHair cellsGap junctionsDistortion product otoacoustic emissionsOuter hair cell electromotilityHair cell electromotilitySevere hearing lossProduct otoacoustic emissionsShorter outer hair cellsHair-bundle movementsOuter pillar cellsLeftward shiftOtoacoustic emissionsAcoustic stimulationDeiters' cellsHearing sensitivityConnexin 26Active cochlear mechanicsNovel findingsPillar cellsBundle movement
2008
Prestin up-regulation in chronic salicylate (aspirin) administration: An implication of functional dependence of prestin expression
Yu N, Zhu M, Johnson B, Liu Y, Jones R, Zhao H. Prestin up-regulation in chronic salicylate (aspirin) administration: An implication of functional dependence of prestin expression. Cellular And Molecular Life Sciences 2008, 65: 2407-2418. PMID: 18560754, PMCID: PMC2548279, DOI: 10.1007/s00018-008-8195-y.Peer-Reviewed Original ResearchConceptsLong-term administrationPrestin expressionSalicylate administrationChronic salicylate administrationDistortion product otoacoustic emissionsNuclear transcription factors c-fosProduct otoacoustic emissionsTranscription factor c-FosOHC electromotilityHearing lossNF-κBAcute inhibitionOtoacoustic emissionsAdministrationC-fosProtein levelsOuter hair cell electromotilityHair cell electromotilityEgr-1Incremental increaseExpressionSalicylateElectromotilityFour-fold
2006
Prestin is expressed on the whole outer hair cell basolateral surface
Yu N, Zhu M, Zhao H. Prestin is expressed on the whole outer hair cell basolateral surface. Brain Research 2006, 1095: 51-58. PMID: 16709400, PMCID: PMC2548272, DOI: 10.1016/j.brainres.2006.04.017.Peer-Reviewed Original Research
2003
Excitation of fluorescent dyes inactivates the outer hair cell integral membrane motor protein prestin and betrays its lateral mobility
Santos-Sacchi J, Zhao HB. Excitation of fluorescent dyes inactivates the outer hair cell integral membrane motor protein prestin and betrays its lateral mobility. Pflügers Archiv - European Journal Of Physiology 2003, 446: 617-622. PMID: 12783229, DOI: 10.1007/s00424-003-1053-8.Peer-Reviewed Original Research