2016
Expression and function of pannexins in the inner ear and hearing
Zhao H. Expression and function of pannexins in the inner ear and hearing. BMC Molecular And Cell Biology 2016, 17: 16. PMID: 27229462, PMCID: PMC4896268, DOI: 10.1186/s12860-016-0095-7.Peer-Reviewed Original ResearchConceptsFunction of pannexinsAuditory sensory hair cellsDistinct expression patternsCell apoptotic pathwaysGap junction genesSensory hair cellsGap junction proteinGene familyATP releaseExpression patternsApoptotic pathwayEndocochlear potentialJunction genesPannexinsActive cochlear amplificationPannexin expressionLateral wallCochlear lateral wallJunction proteinsOrgan of CortiHair cellsCritical roleCochlear amplificationIsoformsStria vascularis
2014
The role of an inwardly rectifying K+ channel (Kir4.1) in the inner ear and hearing loss
Chen J, Zhao H. The role of an inwardly rectifying K+ channel (Kir4.1) in the inner ear and hearing loss. Neuroscience 2014, 265: 137-146. PMID: 24480364, PMCID: PMC4007161, DOI: 10.1016/j.neuroscience.2014.01.036.Peer-Reviewed Original ResearchConceptsInner earGanglion neuronsHearing lossSpiral ganglion neuron degenerationPotassium channelsSatellite glial cellsSpiral ganglion neuronsKir4.1 potassium channelsPathogenesis of deafnessPotassium channel functionNeuron degenerationSeSAME syndromeFunctional impairmentGlial cellsCochlear ganglionTherapeutic strategiesKir4.1 channelsCochlear developmentStria vascularisKir4.1 subunitKir4.1Scala mediaIntermediate cellsAbsence of EpEar
2008
Identification and characterization of pannexin expression in the mammalian cochlea
Wang X, Streeter M, Liu Y, Zhao H. Identification and characterization of pannexin expression in the mammalian cochlea. The Journal Of Comparative Neurology 2008, 512: 336-346. PMID: 19009624, PMCID: PMC2630187, DOI: 10.1002/cne.21898.Peer-Reviewed Original ResearchConceptsSpiral ganglion neuronsCochlear lateral wallDiffuse cytoplasmic labelingMammalian cochleaType II fibrocytesOrgan of CortiBlood vessel cellsOuter sulcus cellsWestern blot analysisDistinct cellular distributionGanglion neuronsPolymerase chain reactionGap junctional proteinRat cochleaInterdental cellsStria vascularisPunctate labelingDeiters' cellsSpiral limbusImmunofluorescent stainingCochlear boneHair cellsBasal cellsSpiral prominencePannexin expression