2017
Progressive age-dependence and frequency difference in the effect of gap junctions on active cochlear amplification and hearing
Zong L, Chen J, Zhu Y, Zhao H. Progressive age-dependence and frequency difference in the effect of gap junctions on active cochlear amplification and hearing. Biochemical And Biophysical Research Communications 2017, 489: 223-227. PMID: 28552523, PMCID: PMC5555358, DOI: 10.1016/j.bbrc.2017.05.137.Peer-Reviewed Original ResearchConceptsActive cochlear amplificationHearing lossCochlear amplificationMice ageGap junctionsAge-related hearing lossSignificant hearing lossPostnatal day 25Cochlear gap junctionsAuditory sensory hair cellsSensory hair cellsNonsyndromic hearing lossHigh incidenceOuter pillar cellsDay 25Deiters' cellsConnexin expressionHair cellsConnexin 26Outer hair cell electromotilityHair cell electromotilityPillar cellsPrevious reportsCochleaAge
2013
Active cochlear amplification is dependent on supporting cell gap junctions
Zhu Y, Liang C, Chen J, Zong L, Chen G, Zhao H. Active cochlear amplification is dependent on supporting cell gap junctions. Nature Communications 2013, 4: 1786. PMID: 23653198, PMCID: PMC3675877, DOI: 10.1038/ncomms2806.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAuditory ThresholdCochlear Microphonic PotentialsConnexin 26ConnexinsEvoked Potentials, Auditory, Brain StemGap JunctionsGene DeletionGene TargetingHair Cells, Auditory, OuterHearing LossLabyrinth Supporting CellsMiceMice, KnockoutMolecular Motor ProteinsNonlinear DynamicsOtoacoustic Emissions, SpontaneousSpiral GanglionConceptsActive cochlear amplificationOuter hair cellsCell gap junctionsHearing lossCochlear amplificationHair cellsGap junctionsDistortion product otoacoustic emissionsOuter hair cell electromotilityHair cell electromotilitySevere hearing lossProduct otoacoustic emissionsShorter outer hair cellsHair-bundle movementsOuter pillar cellsLeftward shiftOtoacoustic emissionsAcoustic stimulationDeiters' cellsHearing sensitivityConnexin 26Active cochlear mechanicsNovel findingsPillar cellsBundle movement
2008
Prestin up-regulation in chronic salicylate (aspirin) administration: An implication of functional dependence of prestin expression
Yu N, Zhu M, Johnson B, Liu Y, Jones R, Zhao H. Prestin up-regulation in chronic salicylate (aspirin) administration: An implication of functional dependence of prestin expression. Cellular And Molecular Life Sciences 2008, 65: 2407-2418. PMID: 18560754, PMCID: PMC2548279, DOI: 10.1007/s00018-008-8195-y.Peer-Reviewed Original ResearchConceptsLong-term administrationPrestin expressionSalicylate administrationChronic salicylate administrationDistortion product otoacoustic emissionsNuclear transcription factors c-fosProduct otoacoustic emissionsTranscription factor c-FosOHC electromotilityHearing lossNF-κBAcute inhibitionOtoacoustic emissionsAdministrationC-fosProtein levelsOuter hair cell electromotilityHair cell electromotilityEgr-1Incremental increaseExpressionSalicylateElectromotilityFour-foldATP activates P2x receptors and requires extracellular Ca++ participation to modify outer hair cell nonlinear capacitance
Yu N, Zhao H. ATP activates P2x receptors and requires extracellular Ca++ participation to modify outer hair cell nonlinear capacitance. Pflügers Archiv - European Journal Of Physiology 2008, 457: 453-461. PMID: 18491132, PMCID: PMC5531446, DOI: 10.1007/s00424-008-0522-5.Peer-Reviewed Original ResearchMeSH Keywords4,4'-Diisothiocyanostilbene-2,2'-Disulfonic AcidAdenosine TriphosphateAnimalsCalciumChelating AgentsEgtazic AcidElectric CapacitanceGuinea PigsHair Cells, Auditory, OuterMembrane PotentialsPatch-Clamp TechniquesPotassiumPurinergic P2 Receptor AntagonistsPyridoxal PhosphateReceptors, Purinergic P2Signal TransductionSodiumSuraminTime FactorsUridine TriphosphateConceptsP2X receptorsATP effectP2Y receptor agonistsMetabotropic purinergic receptorsActive cochlear amplifierEffect of ATPReceptor agonistHearing functionP2Y receptorsPurinergic receptorsDisulfonic acidImportant mediatorReceptorsCell functionOuter hair cell electromotilityHair cell electromotilityIonotropic purinergicCochlear amplifierOHC electromotilityTetraacetic acidATPAgonistsPurinergicVoltage dependenceSuramin
2005
Gap junctional hemichannel-mediated ATP release and hearing controls in the inner ear
Zhao H, Yu N, Fleming C. Gap junctional hemichannel-mediated ATP release and hearing controls in the inner ear. Proceedings Of The National Academy Of Sciences Of The United States Of America 2005, 102: 18724-18729. PMID: 16344488, PMCID: PMC1317927, DOI: 10.1073/pnas.0506481102.Peer-Reviewed Original ResearchConceptsHemichannel-mediated ATP releaseHair cellsGap junctional blockerActive cochlear amplifierAuditory sensory hair cellsSensory hair cellsEffect of ATPP2 receptorsExtracellular Ca2OHC electromotilityCochlear sensitivityATP releaseConnexin gap junctionsExtracellular ATPConnexin expressionInner earImmunofluorescent stainingHearing controlsHearing sensitivityOuter hair cell electromotilityCochleaHair cell electromotilityConnexin hemichannelsCochlear fluidsGap junctional channels