2015
Pannexin1 channels dominate ATP release in the cochlea ensuring endocochlear potential and auditory receptor potential generation and hearing
Chen J, Zhu Y, Liang C, Chen J, Zhao H. Pannexin1 channels dominate ATP release in the cochlea ensuring endocochlear potential and auditory receptor potential generation and hearing. Scientific Reports 2015, 5: 10762. PMID: 26035172, PMCID: PMC4451810, DOI: 10.1038/srep10762.Peer-Reviewed Original ResearchConceptsCochlear lateral wallATP releaseHearing lossCochlear microphonicsPotential generationReceptor potentialReceptor potential generationHair cell lossLateral wallNon-junctional channelsEP generationDeficient miceCell lossEndocochlear potentialHair cellsPathological processesCochleaPhysiological conditionsJunction genesGap junction genesConnexin hemichannelsConnexin isoformsHearingDeficiencyReleasePannexin 1 deficiency can induce hearing loss
Zhao H, Zhu Y, Liang C, Chen J. Pannexin 1 deficiency can induce hearing loss. Biochemical And Biophysical Research Communications 2015, 463: 143-147. PMID: 26002464, PMCID: PMC4464954, DOI: 10.1016/j.bbrc.2015.05.049.Peer-Reviewed Original ResearchConceptsDistortion product otoacoustic emissionsHearing lossAuditory brainstem response recordingsProgressive hearing lossProduct otoacoustic emissionsHigh incidenceCell degenerationOtoacoustic emissionsGap junction proteinAcoustic stimulationCell apoptotic pathwaysHair cellsResponse recordingsGene mutationsJunction proteinsExtensive expressionCochleaActive cochlear mechanicsGap junctionsApoptotic pathwayDeficiencyHearingCritical roleCochlear mechanics
2013
The effects and outcomes of electrolyte disturbances and asphyxia on newborns hearing
Liang C, Hong Q, Jiang T, Gao Y, Yao X, Luo X, Zhuo X, Shinn J, Jones R, Zhao H, Lu G. The effects and outcomes of electrolyte disturbances and asphyxia on newborns hearing. International Journal Of Pediatric Otorhinolaryngology 2013, 77: 1072-1076. PMID: 23648318, PMCID: PMC3738180, DOI: 10.1016/j.ijporl.2013.03.031.Peer-Reviewed Original ResearchConceptsElectrolyte disturbancesInfant HearingTEOAE testHearing outcomesFull-term infantsOtoacoustic emission testHigh-risk factorsMonths of agePreterm infantsNewborn hearingAsphyxiaSignificant impairmentInfantsHypocalcaemiaPass rateSignificant reductionOutcomesHearingLow recovery ratesNewbornsImpairmentRecovery rateMonths