2021
Excess extracellular K+ causes inner hair cell ribbon synapse degeneration
Zhao H, Zhu Y, Liu L. Excess extracellular K+ causes inner hair cell ribbon synapse degeneration. Communications Biology 2021, 4: 24. PMID: 33398038, PMCID: PMC7782724, DOI: 10.1038/s42003-020-01532-w.Peer-Reviewed Original ResearchConceptsCochlear synaptopathySynapse degenerationRibbon synapsesNoise exposureNoise-induced cochlear synaptopathyInner hair cell ribbon synapsesIHC ribbon synapsesGlutamate receptor agonistsBK channel blockersHair cell ribbon synapsesReceptor agonistFirst synapseChannel blockersHearing lossIHC ribbonsHearing disordersDegenerationBK channelsPotential targetSynaptopathyAuditory systemSynapsesExposureSwellingExcitotoxicity
2017
Hypothesis of K+-Recycling Defect Is Not a Primary Deafness Mechanism for Cx26 (GJB2) Deficiency
Zhao H. Hypothesis of K+-Recycling Defect Is Not a Primary Deafness Mechanism for Cx26 (GJB2) Deficiency. Frontiers In Molecular Neuroscience 2017, 10: 162. PMID: 28603488, PMCID: PMC5445178, DOI: 10.3389/fnmol.2017.00162.Peer-Reviewed Original ResearchHearing lossDeafness mechanismCx26 deficiencyInner ear gap junctionsHair cell degenerationNonsyndromic hearing lossDisruption of permeabilityCongenital deafnessCell degenerationHair cellsHair cell excitationHereditary deafnessCell excitationConnexin26 MutationsGap junctional channelsGap junctionsDevelopmental disordersDeficiencyDeafnessExtracellular spaceReview articleJunctional channelsDegeneration