Cellular and Deafness Mechanisms Underlying Connexin Mutation-Induced Hearing Loss – A Common Hereditary Deafness
Wingard J, Zhao H. Cellular and Deafness Mechanisms Underlying Connexin Mutation-Induced Hearing Loss – A Common Hereditary Deafness. Frontiers In Cellular Neuroscience 2015, 9: 202. PMID: 26074771, PMCID: PMC4448512, DOI: 10.3389/fncel.2015.00202.Peer-Reviewed Original ResearchHearing lossPathological changesDeafness mechanismCongenital deafnessActive cochlear amplificationProgressive hearing lossDetailed cellular mechanismsCochlear hair cellsHair cell degenerationHereditary deafnessConnexin 26 mutationsDistinct pathological changesNon-syndromic hearing lossProfound congenital deafnessAuditory phenotypeHigh incidenceTherapeutic strategiesGap junctional proteinCell degenerationConnexin expressionHair cellsDeafnessCellular mechanismsLate childhoodCx26 mutations