2015
Connexin26 gap junction mediates miRNA intercellular genetic communication in the cochlea and is required for inner ear development
Zhu Y, Zong L, Mei L, Zhao H. Connexin26 gap junction mediates miRNA intercellular genetic communication in the cochlea and is required for inner ear development. Scientific Reports 2015, 5: 15647. PMID: 26490746, PMCID: PMC4614881, DOI: 10.1038/srep15647.Peer-Reviewed Original ResearchConceptsGenetic communicationOrgan developmentInner ear gap junctionsIntercellular communicationGap junctionsCochlear developmentInner ear developmentNon-coding RNAsCx26 knockout miceEar developmentGene expressionIntercellular transferCx26 deficiencyMiR-96 expressionCx30 deficiencyDevelopmental disordersPredominant isoformCell proliferationDeletionCx26Critical roleKnockout miceExpressionMiRNAsMicroRNAs
2014
The role of an inwardly rectifying K+ channel (Kir4.1) in the inner ear and hearing loss
Chen J, Zhao H. The role of an inwardly rectifying K+ channel (Kir4.1) in the inner ear and hearing loss. Neuroscience 2014, 265: 137-146. PMID: 24480364, PMCID: PMC4007161, DOI: 10.1016/j.neuroscience.2014.01.036.Peer-Reviewed Original ResearchConceptsInner earGanglion neuronsHearing lossSpiral ganglion neuron degenerationPotassium channelsSatellite glial cellsSpiral ganglion neuronsKir4.1 potassium channelsPathogenesis of deafnessPotassium channel functionNeuron degenerationSeSAME syndromeFunctional impairmentGlial cellsCochlear ganglionTherapeutic strategiesKir4.1 channelsCochlear developmentStria vascularisKir4.1 subunitKir4.1Scala mediaIntermediate cellsAbsence of EpEar