2012
ATP activates P2X receptors to mediate gap junctional coupling in the cochlea
Zhu Y, Zhao H. ATP activates P2X receptors to mediate gap junctional coupling in the cochlea. Biochemical And Biophysical Research Communications 2012, 426: 528-532. PMID: 22982314, PMCID: PMC3471361, DOI: 10.1016/j.bbrc.2012.08.119.Peer-Reviewed Original ResearchConceptsP2X receptorsGap junctional couplingCochlear gap junctionsP2Y receptor agonist UTPGap junctionsJunctional couplingP2X receptor antagonistMetabotropic purinergic receptorsReceptor agonist UTPStimulation of ATPPhysiological levelsReceptor antagonistP2Y receptorsPurinergic controlPurinergic receptorsBenzoylbenzoyl-ATPNoise stressReceptorsIonic homeostasisCochleaDisulfonic acidCritical roleIntercellular channelsATPCells
2010
ATP-mediated potassium recycling in the cochlear supporting cells
Zhu Y, Zhao H. ATP-mediated potassium recycling in the cochlear supporting cells. Purinergic Signalling 2010, 6: 221-229. PMID: 20806014, PMCID: PMC2912999, DOI: 10.1007/s11302-010-9184-9.Peer-Reviewed Original ResearchExtracellular concentrationPurinergic receptor antagonistsMembrane potentialCochlear supporting cellsNegative membrane potentialsP2X7 antagonistsReceptor antagonistP2X receptorsInward currentsCell depolarizationPathological conditionsPotassium recyclingSupporting cellsAntagonistConcentration of ATPIonic homeostasisCellsDisulfonic acidCritical roleATPCochlear
2001
Long-term natural culture of cochlear sensory epithelia of guinea pigs
Zhao H. Long-term natural culture of cochlear sensory epithelia of guinea pigs. Neuroscience Letters 2001, 315: 73-76. PMID: 11711218, DOI: 10.1016/s0304-3940(01)02357-6.Peer-Reviewed Original ResearchConceptsCochlear sensory epitheliumCochlear sensory epithelial cellsSensory epithelial cellsSensory epitheliumHair cell markersCochlear cell lineIsolated cell clonesCochlear cellsEpithelial morphotypeGenetic manipulationProtein ZO-1Genetic studiesValuable cell sourceCulture cellsGuinea pigsCell linesEpithelial cellsZO-1Tight junctionsCell markersNatural cultureCell sourceCellsCell clonesCulture mediumChlorpromazine Alters Outer Hair Cell Electromotility
Lue A, Zhao H, Brownell W. Chlorpromazine Alters Outer Hair Cell Electromotility. Otolaryngology 2001, 125: 71-76. PMID: 11458218, DOI: 10.1067/mhn.2001.116446.Peer-Reviewed Original ResearchConceptsOuter hair cellsHair cellsDose-dependent depolarizationGuinea pig outer hair cellsEffect of chlorpromazineElectromotile responseAntipsychotic medicationChlorpromazine treatmentHearing thresholdsLarge dosesCochlear sensitivityOtoacoustic emissionsInner earChlorpromazineOuter Hair Cell ElectromotilityHair cell electromotilityOHC electromotilityMembrane voltageRecording conditionsCellsMedicationsResponseElectromotility
2000
Directional rectification of gap junctional voltage gating between Dieters cells in the inner ear of guinea pig
Zhao H. Directional rectification of gap junctional voltage gating between Dieters cells in the inner ear of guinea pig. Neuroscience Letters 2000, 296: 105-108. PMID: 11108992, DOI: 10.1016/s0304-3940(00)01626-8.Peer-Reviewed Original ResearchVoltage- and Tension-Dependent Lipid Mobility in the Outer Hair Cell Plasma Membrane
Oghalai J, Zhao H, Kutz J, Brownell W. Voltage- and Tension-Dependent Lipid Mobility in the Outer Hair Cell Plasma Membrane. Science 2000, 287: 658-661. PMID: 10650000, PMCID: PMC1976274, DOI: 10.1126/science.287.5453.658.Peer-Reviewed Original ResearchConceptsCell plasma membranePlasma membraneMembrane tensionOuter hair cell plasma membraneLipid-protein interactionsMembrane fluidityForce-generating motorsMammalian hearingLipid mobilityLipid lateral diffusionHair cellsOuter hair cellsCell depolarizationExquisite sensitivityMembraneLateral diffusionMedium osmolalityHyposmotic challengeCellsDynamic changesTransmembraneElectromotilityFluidityVoltage dependenceDrugs results
1999
Auditory collusion and a coupled couple of outer hair cells
Zhao H, Santos-Sacchi J. Auditory collusion and a coupled couple of outer hair cells. Nature 1999, 399: 359-362. PMID: 10360573, DOI: 10.1038/20686.Peer-Reviewed Original Research