2024
Modeling seizure networks in neuron-glia cultures using microelectrode arrays
Boddeti U, Langbein J, McAfee D, Altshuler M, Bachani M, Zaveri H, Spencer D, Zaghloul K, Ksendzovsky A. Modeling seizure networks in neuron-glia cultures using microelectrode arrays. Frontiers In Network Physiology 2024, 4: 1441345. PMID: 39290793, PMCID: PMC11405204, DOI: 10.3389/fnetp.2024.1441345.Peer-Reviewed Original ResearchNetwork changesSeizure networkSeizure modelsDays of chronic treatmentDimensionality reductionNetwork developmentDrug-resistant epilepsyNeuron-glia culturesMean firing rateNetworkTreatment failureChronic treatmentMicroelectrode arraysResection surgeryRetrospective studyFiring rateSeizuresExperience seizuresNeurological disordersStability of infraslow correlation structure in time-shifted intracranial EEG signals
Joshi R, Duckrow R, Goncharova I, Hirsch L, Spencer D, Godwin D, Zaveri H. Stability of infraslow correlation structure in time-shifted intracranial EEG signals. Frontiers In Network Physiology 2024, 4: 1441294. PMID: 39258030, PMCID: PMC11384574, DOI: 10.3389/fnetp.2024.1441294.Peer-Reviewed Original ResearchInfraslow activityContact pairsFrequency bandMagnitude-squared coherenceAntiseizure medicationsMedically refractory epilepsy patientsElectrode contact pairsHigher-frequency activityRefractory epilepsy patientsDC-coupled recordingsIcEEG epochsEEG frequency bandsEnvelope correlationOptimal parametersClinical relevanceSeizure riskIntracranial EEGEpilepsy patientsPatientsIntracranial EEG signalsTaperTraditional EEG frequency bandsMapping the structure-function relationship along macroscale gradients in the human brain
Collins E, Chishti O, Obaid S, McGrath H, King A, Shen X, Arora J, Papademetris X, Constable R, Spencer D, Zaveri H. Mapping the structure-function relationship along macroscale gradients in the human brain. Nature Communications 2024, 15: 7063. PMID: 39152127, PMCID: PMC11329792, DOI: 10.1038/s41467-024-51395-6.Peer-Reviewed Original ResearchConceptsStructure-function correspondenceBrain regionsMacroscale gradientWhite matter connectivityHuman brain regionsStructure-function couplingNeural network propertiesAssociation cortexCognitive functionBridging neuroscienceFunctional coactivationOrganizational axisCortical thicknessHuman brainMotor cortexLanguage processingBrainCortexMotor functionNatural language processingNetwork propertiesMotorNeuroscienceNatural languageData repositoriesA CMOS Nanosensing System For Continuous Brain Multianalyte Monitoring
Gu Y, Vazquez J, Murray D, Zaveri H, Spencer D. A CMOS Nanosensing System For Continuous Brain Multianalyte Monitoring. 2024, 00: 693-697. DOI: 10.1109/ectc51529.2024.00113.Peer-Reviewed Original ResearchAntiseizure Medications in Post-stroke Seizures: A Systematic Review and Network Meta-analysis (P8-1.012)
Misra S, Dawson J, Kwan P, Kasner S, Grotta J, Larsson D, Tanaka T, Zaveri H, Wang S, Khan E, Funaro M, Perla S, Dev P, Hussain T, Liebeskind D, Yasuda C, Elshahat A, Hitawala G, Wang E, Kitagawa R, Pathak A, Zhao Y, Scalzo F, Ihara M, Zelano J, Sunnerhagen K, Walters M, Jette N, Quinn T, Mishra N. Antiseizure Medications in Post-stroke Seizures: A Systematic Review and Network Meta-analysis (P8-1.012). Neurology 2024, 102 DOI: 10.1212/wnl.0000000000205632.Peer-Reviewed Original ResearchSystematic 1 Hz direct electrical stimulation for seizure induction: A reliable method for localizing seizure onset zone and predicting seizure freedom
Sivaraju A, Quraishi I, Collins E, McGrath H, Ramos A, Turk-Browne N, Zaveri H, Damisah E, Spencer D, Hirsch L. Systematic 1 Hz direct electrical stimulation for seizure induction: A reliable method for localizing seizure onset zone and predicting seizure freedom. Brain Stimulation 2024, 17: 339-345. PMID: 38490472, DOI: 10.1016/j.brs.2024.03.011.Peer-Reviewed Original ResearchSeizure inductionSeizure onset zoneSurgical outcomesHabitual seizuresOnset zonePredicting seizure freedomExcellent surgical outcomesProspective cohort studyMann-Whitney testConsecutive patientsFisher's exactSeizure freedomRefractory epilepsyCohort studyPost-surgeryInsular regionsMann-WhitneyPatientsIntracranial EEGSeizuresLocalizing seizure onset zonesStimulationElectrical stimulationMedial temporal regionsTemporal regions
2023
Outcomes in Patients With Poststroke Seizures
Misra S, Kasner S, Dawson J, Tanaka T, Zhao Y, Zaveri H, Eldem E, Vazquez J, Silva L, Mohidat S, Hickman L, Khan E, Funaro M, Nicolo J, Mazumder R, Yasuda C, Sunnerhagen K, Ihara M, Ross J, Liebeskind D, Kwan P, Quinn T, Engel J, Mishra N. Outcomes in Patients With Poststroke Seizures. JAMA Neurology 2023, 80: 1155-1165. PMID: 37721736, PMCID: PMC10507596, DOI: 10.1001/jamaneurol.2023.3240.Peer-Reviewed Original ResearchConceptsPoststroke seizuresPoor functional outcomeLate seizuresEarly seizuresStroke subtypesFunctional outcomeOdds ratioSystematic reviewJoanna Briggs Institute toolsHemorrhagic stroke subtypesOutcomes of patientsHistory of strokeTrials of interventionsRisk of biasMeta-Analyses (PRISMA) checklistPreferred Reporting ItemsMeta-regression analysisWeb of ScienceRecurrent strokeGreater disabilityPoor outcomeDementia riskSubgroup analysisBias assessmentEgger's testQuantitative assessment of burst suppression as a predictor of seizure recurrence in refractory status epilepticus
Fong M, Pu K, Jadav R, Khan T, Hirsch L, Zaveri H. Quantitative assessment of burst suppression as a predictor of seizure recurrence in refractory status epilepticus. Clinical Neurophysiology 2023, 150: 98-105. PMID: 37060844, PMCID: PMC11265649, DOI: 10.1016/j.clinph.2023.03.011.Peer-Reviewed Original ResearchSeizure forecasting: Where do we stand?
Andrzejak R, Zaveri H, Schulze‐Bonhage A, Leguia M, Stacey W, Richardson M, Kuhlmann L, Lehnertz K. Seizure forecasting: Where do we stand? Epilepsia 2023, 64: s62-s71. PMID: 36780237, PMCID: PMC10423299, DOI: 10.1111/epi.17546.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2022
High-resolution cortical parcellation based on conserved brain landmarks for localization of multimodal data to the nearest centimeter
McGrath H, Zaveri H, Collins E, Jafar T, Chishti O, Obaid S, Ksendzovsky A, Wu K, Papademetris X, Spencer D. High-resolution cortical parcellation based on conserved brain landmarks for localization of multimodal data to the nearest centimeter. Scientific Reports 2022, 12: 18778. PMID: 36335146, PMCID: PMC9637135, DOI: 10.1038/s41598-022-21543-3.Peer-Reviewed Original ResearchConceptsEpilepsy surgery cohortStandardized brain regionsBrain structure-function relationshipsSurgery cohortClinical usefulnessBrain metricsAnatomical locationBrain regionsBrain localizationCortical parcellationOwn unique benefitsIntracranial electroencephalographyAnatomical designationBrain anatomyHuman brain anatomyHuman brainBrain atlasBrain landmarksBrain atlasesParcellationMagnetic resonanceNearest centimeterAnatomical featuresAnatomyCortical localizationCellular recovery after prolonged warm ischaemia of the whole body
Andrijevic D, Vrselja Z, Lysyy T, Zhang S, Skarica M, Spajic A, Dellal D, Thorn SL, Duckrow RB, Ma S, Duy PQ, Isiktas AU, Liang D, Li M, Kim SK, Daniele SG, Banu K, Perincheri S, Menon MC, Huttner A, Sheth KN, Gobeske KT, Tietjen GT, Zaveri HP, Latham SR, Sinusas AJ, Sestan N. Cellular recovery after prolonged warm ischaemia of the whole body. Nature 2022, 608: 405-412. PMID: 35922506, PMCID: PMC9518831, DOI: 10.1038/s41586-022-05016-1.Peer-Reviewed Original ResearchConceptsSingle-nucleus transcriptomic analysesSpecific gene expression patternsCellular recoveryGene expression patternsCellular processesMammalian cellsTranscriptomic analysisLarge mammalsExpression patternsCellular repair processesCell deathComprehensive resourceUnderappreciated potentialPhysiological challengesTissue integrityRepair processSpecific changesPorcine brainMammalsOrgansMultiple organsPrognostication of responsive neurostimulation system responsiveness using presurgical magnetoencephalography
Joshi RB, Zaveri HP. Prognostication of responsive neurostimulation system responsiveness using presurgical magnetoencephalography. Brain Communications 2022, 4: fcac114. PMID: 35611311, PMCID: PMC9123844, DOI: 10.1093/braincomms/fcac114.Peer-Reviewed Original ResearchCatch the Rhythm!
Eid T, Zaveri HP. Catch the Rhythm! Epilepsy Currents 2022, 22: 249-251. PMID: 36187149, PMCID: PMC9483758, DOI: 10.1177/15357597221099066.Peer-Reviewed Original ResearchPerspectives on Understanding Aberrant Brain Networks in Epilepsy
Sinha N, Joshi R, Sandhu M, Netoff T, Zaveri H, Lehnertz K. Perspectives on Understanding Aberrant Brain Networks in Epilepsy. Frontiers In Network Physiology 2022, 2: 868092. PMID: 36926081, PMCID: PMC10013006, DOI: 10.3389/fnetp.2022.868092.Peer-Reviewed Original ResearchDiscrete cortical areasAberrant brain networksGeneralized seizuresAdjacent cortexSeizure progressionCortical areasEpilepsyNeurological disordersSeizuresAnatomical configurationNetwork diseaseNeural activityBrainAberrant activityBrain networksHuman brainWidespread neural activityPatientsSurgeryCortexDiseaseNovel studyProgression331 Role of Functional Network Formation in Epilepsy
Boddeti U, Bachani M, Moyer M, Owotade J, Serra R, Zaveri H, Ksendzovsky A. 331 Role of Functional Network Formation in Epilepsy. Neurosurgery 2022, 68: 75-76. DOI: 10.1227/neu.0000000000001880_331.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsEpileptogenic focusFocal epilepsyTetanic stimulationGood surgical outcomePrimary mixed culturesMulti-electrode arraysCortical epilepsyRefractory seizuresSurgical resectionSurgical outcomesEpileptogenic networksVitro stimulationCortical neuronsRat pupsSeizure onsetAxonal boutonsEpilepsy patientsSurgery decisionDaily stimulationDendritic spinesSeizure formationEpilepsyVitro modelStimulationNetwork disorder
2021
International Post Stroke Epilepsy Research Consortium (IPSERC): A consortium to accelerate discoveries in preventing epileptogenesis after stroke
Mishra NK, Engel J, Liebeskind DS, Sharma VK, Hirsch LJ, Kasner SE, French JA, Devinsky O, Friedman A, Dawson J, Quinn TJ, Selim M, de Havenon A, Yasuda CL, Cendes F, Benninger F, Zaveri HP, Burneo JG, Srivastava P, Singh M, Bhatia R, Vishnu VY, Bentes C, Ferro J, Weiss S, Sivaraju A, Kim JA, Galovic M, Gilmore EJ, Pitkänen A, Davis K, Sansing LH, Sheth KN, Paz JT, Singh A, Sheth S, Worrall BB, Grotta JC, Casillas-Espinos PM, Chen Z, Nicolo JP, Yan B, Kwan P, Consortium F. International Post Stroke Epilepsy Research Consortium (IPSERC): A consortium to accelerate discoveries in preventing epileptogenesis after stroke. Epilepsy & Behavior 2021, 127: 108502. PMID: 34968775, DOI: 10.1016/j.yebeh.2021.108502.Peer-Reviewed Original ResearchPassive Localization of the Central Sulcus during Sleep Based on Intracranial EEG
Alkawadri R, Zaveri HP, Sheth KN, Spencer DD. Passive Localization of the Central Sulcus during Sleep Based on Intracranial EEG. Cerebral Cortex 2021, 32: 3726-3735. PMID: 34921723, PMCID: PMC9764437, DOI: 10.1093/cercor/bhab443.Peer-Reviewed Original ResearchConceptsCentral sulcusMotor cortexMotor areaLeg motor areaPrimary motor cortexIntracranial EEG monitoringTongue motor areaLocal network activityMotor/premotorSM cortexIntractable epilepsySensorimotor cortexAnterior bankNREM sleepSensory cortexEEG monitoringZ-scoreHigher EEGCortexIntracranial EEGSignificant differencesPatientsSleepNetwork activityPrimary handCombining Transcranial Doppler and EEG Data to Predict Delayed Cerebral Ischemia After Subarachnoid Hemorrhage
Chen HY, Elmer J, Zafar SF, Ghanta M, Moura Junior V, Rosenthal ES, Gilmore EJ, Hirsch LJ, Zaveri HP, Sheth KN, Petersen NH, Westover MB, Kim JA. Combining Transcranial Doppler and EEG Data to Predict Delayed Cerebral Ischemia After Subarachnoid Hemorrhage. Neurology 2021, 98: e459-e469. PMID: 34845057, PMCID: PMC8826465, DOI: 10.1212/wnl.0000000000013126.Peer-Reviewed Original ResearchSmall loci of astroglial glutamine synthetase deficiency in the postnatal brain cause epileptic seizures and impaired functional connectivity
Farina MG, Sandhu MRS, Parent M, Sanganahalli BG, Derbin M, Dhaher R, Wang H, Zaveri HP, Zhou Y, Danbolt NC, Hyder F, Eid T. Small loci of astroglial glutamine synthetase deficiency in the postnatal brain cause epileptic seizures and impaired functional connectivity. Epilepsia 2021, 62: 2858-2870. PMID: 34536233, PMCID: PMC9006438, DOI: 10.1111/epi.17072.Peer-Reviewed Original ResearchConceptsPostnatal brainFunctional connectivityContinuous video-electroencephalographic recordingSpontaneous recurrent seizuresPathogenesis of epilepsyGlutamine synthetase deficiencyVideo-electroencephalographic recordingsSpecific animal modelsEx vivo studySeizure thresholdAdult patientsRecurrent seizuresFocal epilepsyAdeno-associated virusHippocampal formationAnimal modelsFocal mannerEpileptic seizuresGS deficiencySmall lociSynthetase deficiencyEpilepsyGradual returnVivo studiesBrainArtificial neural network trained on smartphone behavior can trace epileptiform activity in epilepsy
Duckrow RB, Ceolini E, Zaveri HP, Brooks C, Ghosh A. Artificial neural network trained on smartphone behavior can trace epileptiform activity in epilepsy. IScience 2021, 24: 102538. PMID: 34308281, PMCID: PMC8257969, DOI: 10.1016/j.isci.2021.102538.Peer-Reviewed Original Research