2021
Small loci of astroglial glutamine synthetase deficiency in the postnatal brain cause epileptic seizures and impaired functional connectivity
Farina MG, Sandhu MRS, Parent M, Sanganahalli BG, Derbin M, Dhaher R, Wang H, Zaveri HP, Zhou Y, Danbolt NC, Hyder F, Eid T. Small loci of astroglial glutamine synthetase deficiency in the postnatal brain cause epileptic seizures and impaired functional connectivity. Epilepsia 2021, 62: 2858-2870. PMID: 34536233, PMCID: PMC9006438, DOI: 10.1111/epi.17072.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAstrocytesBrainEpilepsyGlial Fibrillary Acidic ProteinGlutamate-Ammonia LigaseGlutamineHumansMetabolic DiseasesMiceSeizuresConceptsPostnatal brainFunctional connectivityContinuous video-electroencephalographic recordingSpontaneous recurrent seizuresPathogenesis of epilepsyGlutamine synthetase deficiencyVideo-electroencephalographic recordingsSpecific animal modelsEx vivo studySeizure thresholdAdult patientsRecurrent seizuresFocal epilepsyAdeno-associated virusHippocampal formationAnimal modelsFocal mannerEpileptic seizuresGS deficiencySmall lociSynthetase deficiencyEpilepsyGradual returnVivo studiesBrain
2008
Neurometabolism in human epilepsy
Pan JW, Williamson A, Cavus I, Hetherington HP, Zaveri H, Petroff OA, Spencer DD. Neurometabolism in human epilepsy. Epilepsia 2008, 49: 31-41. PMID: 18304254, PMCID: PMC3657747, DOI: 10.1111/j.1528-1167.2008.01508.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrain DiseasesBrain MappingCarbon IsotopesDominance, CerebralElectrodes, ImplantedElectroencephalographyEpilepsyGamma-Aminobutyric AcidGlucoseHippocampusHumansLimbic SystemMagnetic Resonance SpectroscopyMetabolic DiseasesMicrodialysisMitochondrial DiseasesNeural PathwaysNeuronsPositron-Emission TomographyRatsSynaptic TransmissionConceptsNeurometabolic dysfunctionMagnetic resonance spectroscopic imagingHuman epilepsyEpileptic brainHippocampal resectionSclerotic hippocampusPathophysiologic aspectsEpileptogenic processMicrodialysis measuresExtracellular glutamateEpileptic dysfunctionEnergetic dysfunctionHuman studiesDysfunctionNeurotransmitter cyclingNoninvasive functional imagingProfound decreaseMitochondrial injuryBrain functionEpilepsyFunctional imagingMetabolic imagingBrainIntracranial EEGNeurometabolism