2024
Mapping the structure-function relationship along macroscale gradients in the human brain
Collins E, Chishti O, Obaid S, McGrath H, King A, Shen X, Arora J, Papademetris X, Constable R, Spencer D, Zaveri H. Mapping the structure-function relationship along macroscale gradients in the human brain. Nature Communications 2024, 15: 7063. PMID: 39152127, PMCID: PMC11329792, DOI: 10.1038/s41467-024-51395-6.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrainBrain MappingCognitionFemaleHumansMagnetic Resonance ImagingMaleMotor CortexNatural Language ProcessingNerve NetStructure-Activity RelationshipWhite MatterConceptsStructure-function correspondenceBrain regionsMacroscale gradientWhite matter connectivityHuman brain regionsStructure-function couplingNeural network propertiesAssociation cortexCognitive functionBridging neuroscienceFunctional coactivationOrganizational axisCortical thicknessHuman brainMotor cortexLanguage processingBrainCortexMotor functionNatural language processingNetwork propertiesMotorNeuroscienceNatural languageData repositories
2022
High-resolution cortical parcellation based on conserved brain landmarks for localization of multimodal data to the nearest centimeter
McGrath H, Zaveri H, Collins E, Jafar T, Chishti O, Obaid S, Ksendzovsky A, Wu K, Papademetris X, Spencer D. High-resolution cortical parcellation based on conserved brain landmarks for localization of multimodal data to the nearest centimeter. Scientific Reports 2022, 12: 18778. PMID: 36335146, PMCID: PMC9637135, DOI: 10.1038/s41598-022-21543-3.Peer-Reviewed Original ResearchMeSH KeywordsBrainBrain MappingHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingNeuroimagingNeurosciencesConceptsEpilepsy surgery cohortStandardized brain regionsBrain structure-function relationshipsSurgery cohortClinical usefulnessBrain metricsAnatomical locationBrain regionsBrain localizationCortical parcellationOwn unique benefitsIntracranial electroencephalographyAnatomical designationBrain anatomyHuman brain anatomyHuman brainBrain atlasBrain landmarksBrain atlasesParcellationMagnetic resonanceNearest centimeterAnatomical featuresAnatomyCortical localization
2013
Seizure localization using three-dimensional surface projections of intracranial EEG power
Lee HW, Youngblood MW, Farooque P, Han X, Jhun S, Chen WC, Goncharova I, Vives K, Spencer DD, Zaveri H, Hirsch LJ, Blumenfeld H. Seizure localization using three-dimensional surface projections of intracranial EEG power. NeuroImage 2013, 83: 616-626. PMID: 23850575, PMCID: PMC3815983, DOI: 10.1016/j.neuroimage.2013.07.010.Peer-Reviewed Original ResearchMeSH KeywordsBrainBrain MappingElectroencephalographyEpilepsyFemaleHumansImaging, Three-DimensionalMagnetic Resonance ImagingMaleSeizuresConceptsEpilepsy surgerySeizure localizationGood surgical outcomeEEG powerIntractable epilepsy patientsAgreement rateNormal brain functionOverall agreement ratePoor outcomeSurgical outcomesIntractable epilepsyIcEEG recordingsSeizure onsetSublobar localizationEpilepsy patientsIndependent reviewersClinical informationIcEEG dataPatientsBrain functionSurgeryImproved diagnostic methodIntracranial EEGDiagnostic methodsOutcomesIntracranial EEG evaluation of relationship within a resting state network
Duncan D, Duckrow RB, Pincus SM, Goncharova I, Hirsch LJ, Spencer DD, Coifman RR, Zaveri HP. Intracranial EEG evaluation of relationship within a resting state network. Clinical Neurophysiology 2013, 124: 1943-1951. PMID: 23790525, DOI: 10.1016/j.clinph.2013.03.028.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBrain MappingChildElectroencephalographyEpilepsy, Frontal LobeFemaleGyrus CinguliHumansMagnetic Resonance ImagingMaleNerve NetParietal LobeYoung AdultConceptsDefault mode networkIntracranial EEG evaluationMode networkLocalization-related epilepsyCross-approximate entropyNeuronal involvementHemodynamic measurementsIntracranial EEG recordingsEEG evaluationBackground activityGamma powerFMRI studyIntracranial EEGBrain activityPatientsEEG recordingsLow levelsT2EpilepsyMagnitude squared coherenceT1
2012
Estimating correlation for a real-time measure of connectivity
Arunkumar A, Panday A, Joshi B, Ravindran A, Zaveri H. Estimating correlation for a real-time measure of connectivity. Annual International Conference Of The IEEE Engineering In Medicine And Biology Society (EMBC) 2012, 2012: 5190-5193. PMID: 23367098, DOI: 10.1109/embc.2012.6347163.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsBrainBrain MappingComputer SystemsConnectomeHumansMagnetic Resonance ImagingNerve NetReproducibility of ResultsSensitivity and SpecificityStatistics as TopicConceptsReal-time constraintsIBM Cell Broadband EngineCell Broadband EnginePair-wise correlationsBroadband EngineParallel algorithmExecution timeIntel XeonComputational requirementsEfficient implementationDifferent acquisition parametersReal-time estimationMultiple channelsAlgorithmConnectivityReal-time measuresXeonAcquisition parametersConstraintsEngineImplementationConnectivity analysisRequirementsTime series measuresInstances
2008
Decreased hippocampal volume on MRI is associated with increased extracellular glutamate in epilepsy patients
Cavus I, Pan JW, Hetherington HP, Abi‐Saab W, Zaveri HP, Vives KP, Krystal JH, Spencer SS, Spencer DD. Decreased hippocampal volume on MRI is associated with increased extracellular glutamate in epilepsy patients. Epilepsia 2008, 49: 1358-1366. PMID: 18410365, DOI: 10.1111/j.1528-1167.2008.01603.x.Peer-Reviewed Original ResearchConceptsTemporal lobe epilepsyHippocampal volumeClinical factorsHippocampal atrophyEpileptogenic hippocampusGABA levelsNeurochemical levelsElevated extracellular glutamate levelsContralateral hippocampal volumeIntracranial EEG evaluationMedication-resistant epilepsyRefractory TLE patientsHigh seizure frequencyRelevant clinical factorsSmaller hippocampal volumesExtracellular glutamate levelsFebrile seizure historyTreatment of epilepsySeizure frequencyLobe epilepsySeizure historyTLE patientsAtrophic hippocampusGlutamate levelsExtracellular glutamateInterictal spikes on intracranial recording: Behavior, physiology, and implications
Spencer SS, Goncharova II, Duckrow RB, Novotny EJ, Zaveri HP. Interictal spikes on intracranial recording: Behavior, physiology, and implications. Epilepsia 2008, 49: 1881-1892. PMID: 18479398, DOI: 10.1111/j.1528-1167.2008.01641.x.Peer-Reviewed Original ResearchConceptsInterictal spikesAED withdrawalSeizure onsetSpike rateMedial temporal lobe seizuresAntiepileptic drug changesRefractory epileptic patientsTemporal lobe seizuresOnset seizuresDrug changesEpileptic patientsNeocortical locationsClinical meaningMedial temporalSeizuresIntracranial electrodesDays of recordingAED mechanismsIntracranial recordingsSignificant increaseAEDsPrevious reportsOnsetSpecific effectsWithdrawal