2016
Progressive neuronal activation accompanies epileptogenesis caused by hippocampal glutamine synthetase inhibition
Albright B, Dhaher R, Wang H, Harb R, Lee TW, Zaveri H, Eid T. Progressive neuronal activation accompanies epileptogenesis caused by hippocampal glutamine synthetase inhibition. Experimental Neurology 2016, 288: 122-133. PMID: 27769717, PMCID: PMC5547560, DOI: 10.1016/j.expneurol.2016.10.007.Peer-Reviewed Original ResearchConceptsMesial temporal lobe epilepsyNeuronal activationHippocampal formationHuman mesial temporal lobe epilepsyAnterior olfactory areaEntorhinal-hippocampal areaProcess of epileptogenesisC-Fos immunohistochemistryTemporal lobe epilepsyTypes of seizuresGlutamine synthetase inhibitionSurgical resectionPiriform cortexSeizure severityLobe epilepsyHippocampal astrocytesEpilepsy developmentEpileptogenic processElectroencephalogram monitoringOlfactory areasPharmacological interventionsSeizure phenotypeBed nucleusMidline thalamusStria terminalis
2015
Effects of site-specific infusions of methionine sulfoximine on the temporal progression of seizures in a rat model of mesial temporal lobe epilepsy
Dhaher R, Wang H, Gruenbaum SE, Tu N, Lee TS, Zaveri HP, Eid T. Effects of site-specific infusions of methionine sulfoximine on the temporal progression of seizures in a rat model of mesial temporal lobe epilepsy. Epilepsy Research 2015, 115: 45-54. PMID: 26220375, PMCID: PMC4677790, DOI: 10.1016/j.eplepsyres.2015.05.005.Peer-Reviewed Original ResearchConceptsMesial temporal lobe epilepsyTemporal lobe epilepsyRecurrent seizuresLateral ventricleLobe epilepsyDentate gyrusEntorhinal cortexDeep entorhinal cortexEntorhinal-hippocampal areaWeek recording periodSite-specific infusionPhosphate-buffered salineDays of infusionAdult laboratory ratsRecording periodMethionine sulfoximineSeizure severitySeizure activitySevere seizuresMetabolism of glutamateRat modelSynaptic transmissionAnatomical distributionHippocampal formationAngular bundle
2014
Ictal spread of medial temporal lobe seizures with and without secondary generalization: An intracranial electroencephalography analysis
Yoo JY, Farooque P, Chen WC, Youngblood MW, Zaveri HP, Gerrard JL, Spencer DD, Hirsch LJ, Blumenfeld H. Ictal spread of medial temporal lobe seizures with and without secondary generalization: An intracranial electroencephalography analysis. Epilepsia 2014, 55: 289-295. PMID: 24417694, PMCID: PMC4103687, DOI: 10.1111/epi.12505.Peer-Reviewed Original ResearchConceptsSecondary generalizationTemporal lobe seizuresFocal seizuresTemporal cortexMedial temporal lobe seizuresCortical regionsLow-voltage fast activityProminent activationAnteromedial temporal lobe resectionTonic-clonic seizuresSeizure-onset patternsTemporal lobe resectionLateral temporal cortexQuality of lifePosterior lateral temporal cortexTemporal lobe areasIntracranial electroencephalography studyMedial temporal lobe areasMedial temporal lobePosterior lateral temporal regionsIctal spreadHippocampal sclerosisSeizure spreadLobe resectionTemporal lobe