2008
Recurrent seizures and brain pathology after inhibition of glutamine synthetase in the hippocampus in rats
Eid T, Ghosh A, Wang Y, Beckström H, Zaveri HP, Lee TS, Lai JC, Malthankar-Phatak GH, de Lanerolle NC. Recurrent seizures and brain pathology after inhibition of glutamine synthetase in the hippocampus in rats. Brain 2008, 131: 2061-2070. PMID: 18669513, PMCID: PMC2724901, DOI: 10.1093/brain/awn133.Peer-Reviewed Original ResearchConceptsMesial temporal lobe epilepsyMesial temporal sclerosisRecurrent seizuresTemporal sclerosisBrain pathologyIntractable mesial temporal lobe epilepsyTemporal lobe epilepsyGlutamine synthetase deficiencyNovel animal modelContinuous microinfusionHippocampal atrophyLobe epilepsyGlutamate excessNeuropathological featuresExtracellular glutamateHippocampal neuronsAnimal modelsTherapeutic interventionsHippocampusSeizuresSclerosisSynthetase deficiencyMinimal injuryPatientsRats
2001
Distinguishing Subtypes of Temporal Lobe Epilepsy with Background Hippocampal Activity
Zaveri H, Duckrow R, De Lanerolle N, Spencer S. Distinguishing Subtypes of Temporal Lobe Epilepsy with Background Hippocampal Activity. Epilepsia 2001, 42: 725-730. PMID: 11422326, DOI: 10.1046/j.1528-1157.2001.00500.x.Peer-Reviewed Original ResearchConceptsMesial temporal sclerosisTemporal lobe epilepsyLobe epilepsySurgical outcomesIntractable temporal lobe epilepsyPoor surgical outcomesGood surgical outcomeMedial temporal structuresMedial temporal lobeDelta band powerTemporal sclerosisRetrospective studyHippocampal tissueBackground EEGSeizure onsetIndividual patientsSurgical proceduresIntracranial monitoringTemporal lobeGamma frequency bandClinical observationsPatientsAnterior hippocampusCell lossSubtypes