2018
2235 15N-Leucine transport across the blood brain barrier is significantly impaired in the glutamine synthetase-inhibited brain
Gruenbaum S, Dhaher R, Behar K, Zaveri H, Erfe M, Eid T. 2235 15N-Leucine transport across the blood brain barrier is significantly impaired in the glutamine synthetase-inhibited brain. Journal Of Clinical And Translational Science 2018, 2: 1-1. PMCID: PMC6808188, DOI: 10.1017/cts.2018.37.Peer-Reviewed Original ResearchIpsilateral hippocampusDentate gyrusAstroglial glutamine synthetaseMicrodialysis guide cannulaBlood-brain barrierImmune system dysfunctionRight dentate gyrusBilateral dentate gyrusL-type amino acid transporterBrief isoflurane anesthesiaArtificial extracellular fluidSignificant increaseGlutamine concentrationImportant therapeutic targetBilateral microdialysis probesAmino acid influxMethionine sulfoximineContralateral hippocampusLiver diseaseBrain ammoniaSynaptic glutamateBrain barrierSystem dysfunctionGuide cannulaIsoflurane anesthesia
2015
Effects of site-specific infusions of methionine sulfoximine on the temporal progression of seizures in a rat model of mesial temporal lobe epilepsy
Dhaher R, Wang H, Gruenbaum SE, Tu N, Lee TS, Zaveri HP, Eid T. Effects of site-specific infusions of methionine sulfoximine on the temporal progression of seizures in a rat model of mesial temporal lobe epilepsy. Epilepsy Research 2015, 115: 45-54. PMID: 26220375, PMCID: PMC4677790, DOI: 10.1016/j.eplepsyres.2015.05.005.Peer-Reviewed Original ResearchConceptsMesial temporal lobe epilepsyTemporal lobe epilepsyRecurrent seizuresLateral ventricleLobe epilepsyDentate gyrusEntorhinal cortexDeep entorhinal cortexEntorhinal-hippocampal areaWeek recording periodSite-specific infusionPhosphate-buffered salineDays of infusionAdult laboratory ratsRecording periodMethionine sulfoximineSeizure severitySeizure activitySevere seizuresMetabolism of glutamateRat modelSynaptic transmissionAnatomical distributionHippocampal formationAngular bundle
2014
5-Aminovaleric acid suppresses the development of severe seizures in the methionine sulfoximine model of mesial temporal lobe epilepsy
Dhaher R, Damisah EC, Wang H, Gruenbaum SE, Ong C, Zaveri HP, Gruenbaum BF, Eid T. 5-Aminovaleric acid suppresses the development of severe seizures in the methionine sulfoximine model of mesial temporal lobe epilepsy. Neurobiology Of Disease 2014, 67: 18-23. PMID: 24632421, PMCID: PMC4035438, DOI: 10.1016/j.nbd.2014.03.006.Peer-Reviewed Original ResearchConceptsMesial temporal lobe epilepsyTemporal lobe epilepsyNumber of seizuresLobe epilepsyHippocampal formationMesial temporal lobe seizuresSevere typeEntorhinal-hippocampal areaExpression of seizuresStages of seizuresTemporal lobe seizuresDorsal hippocampal formationLocalization-related epilepsyMale Sprague-DawleyPotential therapeutic targetSeizure frequencyAlzet pumpsRacine scaleSevere seizuresSecond surgerySprague-DawleyPump placementMethionine sulfoximineGlutamine-glutamateTherapeutic target
2009
The development of recurrent seizures after continuous intrahippocampal infusion of methionine sulfoximine in rats A video-intracranial electroencephalographic study
Wang Y, Zaveri HP, Lee TS, Eid T. The development of recurrent seizures after continuous intrahippocampal infusion of methionine sulfoximine in rats A video-intracranial electroencephalographic study. Experimental Neurology 2009, 220: 293-302. PMID: 19747915, PMCID: PMC2989153, DOI: 10.1016/j.expneurol.2009.08.034.Peer-Reviewed Original ResearchConceptsMesial temporal lobe epilepsyHuman mesial temporal lobe epilepsyRecurrent seizuresNeuronal lossPartial seizuresPathophysiology of mTLEDiffuse neuronal lossSaline-treated animalsTemporal lobe epilepsyMinimal neuronal lossGlutamine synthetase inhibitor methionine sulfoximineEpileptogenic hippocampusHippocampal sclerosisLobe epilepsyElectroencephalogram monitoringStage IElectrophysiological mechanismsSeizuresElectroencephalographic studiesDays durationIntrahippocampal infusionHippocampusInfusionMethionine sulfoximineIntracranial EEG