2016
50 Hz hippocampal stimulation in refractory epilepsy: Higher level of basal glutamate predicts greater release of glutamate
Cavus I, Widi GA, Duckrow RB, Zaveri H, Kennard JT, Krystal J, Spencer DD. 50 Hz hippocampal stimulation in refractory epilepsy: Higher level of basal glutamate predicts greater release of glutamate. Epilepsia 2016, 57: 288-297. PMID: 26749134, DOI: 10.1111/epi.13269.Peer-Reviewed Original ResearchConceptsBasal glutamate levelsRefractory epilepsyGlutamate effluxBasal glutamateGlutamate levelsElectrical stimulationEpileptic hippocampusGlutamate releaseSeizure groupHz stimulationBrain glutamate releaseHippocampus of patientsStimulation-induced increaseEpilepsy monitoring unitStimulation-induced changesEpileptogenic hippocampusInduced seizuresSeizure inductionSpontaneous seizuresInterictal levelsGlutamate increaseAtrophic hippocampusElectroencephalography evaluationHippocampal stimulationHippocampal electrodes
2009
IMAGING | Physiologic Correlates of Metabolic Imaging in Human Epilepsy
Pan J, Williamson A, Cavus I, Zaveri H, Spencer D, Hetherington H. IMAGING | Physiologic Correlates of Metabolic Imaging in Human Epilepsy. 2009, 1568-1573. DOI: 10.1016/b978-012373961-2.00222-8.Peer-Reviewed Original ResearchHuman epilepsyNAA/Cr ratioMetabolic imagingPCr/ATP ratioLocalization/lateralizationMR spectroscopic studiesEpileptic hippocampusMicrodialysis measuresPathophysiologic correlatesSeizure focusNeuropsychologic dataExtracellular glutamateMetabolic dysfunctionMetabolic pathophysiologyVivo MR spectroscopyElectrophysiological functionPhysiologic correlatesEpilepsyMR spectroscopic measurementsMR spectroscopyCr ratioMitochondrial functionMR spectroscopicMemory functionHuman brain