2013
Altered Network Timing in the CA3-CA1 Circuit of Hippocampal Slices from Aged Mice
Kanak DJ, Rose GM, Zaveri HP, Patrylo PR. Altered Network Timing in the CA3-CA1 Circuit of Hippocampal Slices from Aged Mice. PLOS ONE 2013, 8: e61364. PMID: 23593474, PMCID: PMC3620228, DOI: 10.1371/journal.pone.0061364.Peer-Reviewed Original ResearchConceptsCA3-CA1 circuitCA1 stratum pyramidaleSharp-wave ripplesAged miceStratum pyramidaleHippocampal slicesAge groupsCarbachol-induced gamma oscillationsSpontaneous sharp wavesCA1 stratum radiatumGamma oscillationsStratum oriensUnidentified neuronsAged neuronsStratum radiatumCA1 subregionNeuronal activityAdult miceSharp wavesUnit activityRipple oscillationsCollateral responsesMiceCA3Pyramidale
2011
Electrical and Pharmacological Stimuli Reveal a Greater Susceptibility for CA3 Network Excitability in Hippocampal Slices from Aged vs. Adult Fischer 344 Rats.
Kanak DJ, Jones RT, Tokhi A, Willingham AL, Zaveri HP, Rose GM, Patrylo PR. Electrical and Pharmacological Stimuli Reveal a Greater Susceptibility for CA3 Network Excitability in Hippocampal Slices from Aged vs. Adult Fischer 344 Rats. Aging And Disease 2011, 2: 318-31. PMID: 22396884, PMCID: PMC3295070.Peer-Reviewed Original ResearchNetwork excitabilityHippocampal slicesMossy fibersAdult male Fischer 344 ratsMale Fischer 344 ratsExcitotoxic glutamate analoguesCA3 networkFischer 344 ratsHigh-affinity receptorField potential activitySpread of excitabilityHilar stimulationProconvulsive effectsEpileptiform activityBath applicationAged CNSClinical dataRenal clearanceAged ratsAdult ratsAge groupsCA3 subregionExcitabilityRatsGlutamate analogue