2022
Bipolar I and bipolar II subtypes in older age: Results from the Global Aging and Geriatric Experiments in Bipolar Disorder (GAGE‐BD) project
Beunders A, Klaus F, Kok A, Schouws S, Kupka R, Blumberg H, Briggs F, Eyler L, Forester B, Forlenza O, Gildengers A, Jimenez E, Mulsant B, Patrick R, Rej S, Sajatovic M, Sarna K, Sutherland A, Yala J, Vieta E, Villa L, Korten N, Dols A. Bipolar I and bipolar II subtypes in older age: Results from the Global Aging and Geriatric Experiments in Bipolar Disorder (GAGE‐BD) project. Bipolar Disorders 2022, 25: 43-55. PMID: 36377516, PMCID: PMC10265276, DOI: 10.1111/bdi.13271.Peer-Reviewed Original ResearchConceptsBD II patientsStudy cohortBD subtypesSomatic burdenMultivariable analysisGeneral functioningBD-IIGlobal AGEingBD-I patientsCross-sectional analysisClinical factorsClinical differencesSevere depressionPsychiatric hospitalizationBipolar ICognitive impairmentLate onsetPatientsOlder ageDiagnostic definitionSubtypesGeneralized linear mixed modelCohortLinear mixed modelsRandom interceptDemographic and Clinical Characteristics of Antipsychotic Drug-Treated Older Adults with Bipolar Disorder from the Global Aging & Geriatric Experiments in Bipolar Disorder Database (GAGE-BD).
Chen P, Eyler LT, Gildengers A, Beunders AJ, Blumberg HP, Briggs FB, Dols A, Rej S, Forlenza OV, Jimenez E, Mulsant B, Schouws S, Orhan M, Sarna K, Sutherland AN, Vieta E, Tsai S, Yala J, Villa LM, Sajatovic M. Demographic and Clinical Characteristics of Antipsychotic Drug-Treated Older Adults with Bipolar Disorder from the Global Aging & Geriatric Experiments in Bipolar Disorder Database (GAGE-BD). Psychopharmacology Bulletin 2022, 52: 8-33. PMID: 35721813, PMCID: PMC9172555.Peer-Reviewed Original ResearchConceptsOlder age bipolar disorderFirst-generation antipsychoticsAntipsychotic drugsBipolar disorderPsychiatric hospitalizationMean age 63.2 yearsGlobal AGEingClinical characteristicsFrequent hospitalizationsClinical variablesSevere illnessTreatment statusGreater burdenHospitalizationDisorder databaseOlder adultsCross-sectional dataLongitudinal outcomesDisordersPatientsGeneralized mixed modelMultivariate model resultsInternational studiesDrugsObservational analysis
2001
Hippocampal and Anterior Cingulate Activation Deficits in Patients With Geriatric Depression
de Asis J, Stern E, Alexopoulos G, Pan H, Van Gorp W, Blumberg H, Kalayam B, Eidelberg D, Kiosses D, Silbersweig D. Hippocampal and Anterior Cingulate Activation Deficits in Patients With Geriatric Depression. American Journal Of Psychiatry 2001, 158: 1321-1323. PMID: 11481171, DOI: 10.1176/appi.ajp.158.8.1321.Peer-Reviewed Original ResearchConceptsGeriatric depressionActivation deficitsComparison subjectsDorsal anterior cingulate gyrusPositron emission tomography scanEmission tomography scanDepressed geriatric patientsAnterior cingulate gyrusHealthy comparison subjectsElderly patientsGeriatric patientsFrontotemporal functionHippocampal dysfunctionTomography scanPrevalent disorderCingulate gyrusMemory dysfunctionWord generation taskPatientsMemory deficitsHippocampal activityActivation paradigmNeural substratesDepressionDysfunction