2000
Requirement for CD4+ T Lymphocytes in Host Resistance against Cryptococcus neoformans in the Central Nervous System of Immunized Mice
Buchanan K, Doyle H. Requirement for CD4+ T Lymphocytes in Host Resistance against Cryptococcus neoformans in the Central Nervous System of Immunized Mice. Infection And Immunity 2000, 68: 456-462. PMID: 10639404, PMCID: PMC97163, DOI: 10.1128/iai.68.2.456-462.2000.Peer-Reviewed Original ResearchConceptsCentral nervous systemCell-mediated immunityImmune miceT cellsT lymphocytesNervous systemRole of CMIC. neoformansCryptococcus neoformansProtective mechanismT cell numbersSpinal cord homogenateCMI responsesCNS infectionsCryptococcal meningitisLeukocyte accumulationAIDS patientsFatal outcomeImmunized miceVivo depletionCord homogenateIFN-gammaMurine modelHost resistanceCytometric analysis
1999
Role of the C-C chemokine, TCA3, in the protective anticryptococcal cell-mediated immune response.
Doyle H, Murphy J. Role of the C-C chemokine, TCA3, in the protective anticryptococcal cell-mediated immune response. The Journal Of Immunology 1999, 162: 4824-33. PMID: 10202026, DOI: 10.4049/jimmunol.162.8.4824.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, FungalAntigens, FungalCell MovementChemokine CCL1Chemokine CCL3Chemokine CCL4Chemokines, CCCryptococcosisCryptococcus neoformansCytokinesFemaleGelatin Sponge, AbsorbableHypersensitivity, DelayedImmunity, CellularKineticsLeukocytesMacrophage Inflammatory ProteinsMiceMice, Inbred CBANeutrophilsReceptors, CCR8Recombinant ProteinsConceptsDelayed-type hypersensitivityMIP-1alphaC chemokinesAnticryptococcal cell-mediated immune responseCell-mediated immune responsesCell-mediated immune reactionsMacrophage inflammatory protein-1alphaMonocyte chemotactic protein-1DTH reaction sitesNumber of neutrophilsActivated T lymphocytesGelatin sponge modelCMI responsesNaive miceDTH reactionInfected miceCMI reactionsT cellsT lymphocytesImmune responseImmune reactionsCellular infiltrationLymphocytesChemokinesNeutrophils
1997
MIP-1α contributes to the anticryptococcal delayed-type hypersensitivity reaction and protection against Cryptococcus neoformans
Doyle H, Murphy J. MIP-1α contributes to the anticryptococcal delayed-type hypersensitivity reaction and protection against Cryptococcus neoformans. Journal Of Leukocyte Biology 1997, 61: 147-155. PMID: 9021919, DOI: 10.1002/jlb.61.2.147.Peer-Reviewed Original ResearchConceptsMIP-1 alphaMIP-1 alpha levelsDelayed-type hypersensitivity reactionImmunized miceHypersensitivity reactionsC. neoformansCell-mediated immune responsesInflammatory protein-1 alphaCryptococcus neoformansAlpha levelsDTH reaction sitesInflux of neutrophilsNumber of neutrophilsProtein-1 alphaClearance of microorganismsGelatin sponge modelCMI responsesCryptococcal antigenNeutrophil influxNaive miceDTH reactionLeukocyte infiltrationMIP-1αChemotactic cytokinesImmune response