2020
Pregnancy registry: three-year follow-up of children conceived from letrozole, clomiphene, or gonadotropins
Legro RS, Diamond MP, Coutifaris C, Schlaff WD, Alvero R, Casson P, Christman GM, Rosen RM, Cedars MI, Hansen KR, Robinson R, Baker V, Usadi R, Dodson WC, Estes SJ, Kunselman A, Stetter C, Barnhart KT, Coward RM, Trussell JC, Krawetz SA, Santoro N, Huang H, Zhang H, Eisenberg E, Network R. Pregnancy registry: three-year follow-up of children conceived from letrozole, clomiphene, or gonadotropins. Fertility And Sterility 2020, 113: 1005-1013. PMID: 32386612, PMCID: PMC7376442, DOI: 10.1016/j.fertnstert.2019.12.023.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsChild BehaviorChild DevelopmentChild, PreschoolClomipheneCognitionFemaleFertilityFertility AgentsFollow-Up StudiesGesturesGonadotropinsHumansInfantInfertility, FemaleLetrozoleLive BirthMaleOvulation InductionPolycystic Ovary SyndromePregnancyProspective StudiesRandomized Controlled Trials as TopicRegistriesTreatment OutcomeUnited StatesWeight GainConceptsGN groupMultiple pregnancy rateProspective cohort studyPolycystic ovary syndromeChildren of womenInfertility trialsUnexplained infertilityCohort studyII studyMultiple gestationsOvary syndromeHealth centersInfertility treatmentPregnancy rateInfertility therapyMAIN OUTCOMELTZ groupLetrozoleMacArthur-Bates Communicative Development InventoriesAcademic health centersGonadotropinAbnormal scoresClomipheneCC groupDevelopmental Questionnaire
2010
Decision trees for identifying predictors of treatment effectiveness in clinical trials and its application to ovulation in a study of women with polycystic ovary syndrome
Zhang H, Legro RS, Zhang J, Zhang L, Chen X, Huang H, Casson PR, Schlaff WD, Diamond MP, Krawetz SA, Coutifaris C, Brzyski RG, Christman GM, Santoro N, Eisenberg E. Decision trees for identifying predictors of treatment effectiveness in clinical trials and its application to ovulation in a study of women with polycystic ovary syndrome. Human Reproduction 2010, 25: 2612-2621. PMID: 20716558, PMCID: PMC2939757, DOI: 10.1093/humrep/deq210.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAndrogensAnovulationBody Mass IndexClomipheneDecision TreesDrug Therapy, CombinationFemaleFertility Agents, FemaleHumansInfertility, FemaleMetforminOrgan SizeOvulation InductionPolycystic Ovary SyndromePregnancyProinsulinRandomized Controlled Trials as TopicSex Hormone-Binding GlobulinTreatment OutcomeWaist-Hip RatioConceptsPolycystic ovary syndromeCombination of CCClomiphene citrateClinical trialsOvarian volumeOvary syndromeOvulation inductionHigher sex hormone-binding globulin levelsSex hormone-binding globulin levelsHormone-binding globulin levelsTreatment effectivenessHigher baseline insulinHip circumference ratioIncidence of ovulationBaseline physical characteristicsBaseline laboratoryOvulatory rateClinical parametersHigher waistBaseline variablesPredictive biomarkersGlobulin levelsCircumference ratioOvulatory responseTreatment outcomes
2006
Cortical neurogenesis enhanced by chronic perinatal hypoxia
Fagel DM, Ganat Y, Silbereis J, Ebbitt T, Stewart W, Zhang H, Ment LR, Vaccarino FM. Cortical neurogenesis enhanced by chronic perinatal hypoxia. Experimental Neurology 2006, 199: 77-91. PMID: 15916762, DOI: 10.1016/j.expneurol.2005.04.006.Peer-Reviewed Original ResearchConceptsChronic perinatal hypoxiaCerebral cortexPerinatal hypoxiaCortical neurogenesisCessation of hypoxiaInfant mouse brainSubcortical white matterLower cortical layersMature mammalian brainPostnatal day 3Forebrain subventricular zoneBrdU-positive cellsCortical neuron numberAstroglial cell proliferationNormoxic miceNeonatal injuryNeuronal lossBrain weightCortical neuronsNew neuronsCortical volumeNeuronal markersSubventricular zoneJuvenile micePutative neuroblasts
2004
Preoperative Anxiety and Emergence Delirium and Postoperative Maladaptive Behaviors
Kain ZN, Caldwell-Andrews AA, Maranets I, McClain B, Gaal D, Mayes LC, Feng R, Zhang H. Preoperative Anxiety and Emergence Delirium and Postoperative Maladaptive Behaviors. Anesthesia & Analgesia 2004, 99: 1648-1654. PMID: 15562048, DOI: 10.1213/01.ane.0000136471.36680.97.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PsychologicalAge FactorsAlgorithmsAnesthesia Recovery PeriodAnesthesia, GeneralAnxietyChildChild, PreschoolDatabases, FactualDeliriumFamilyFemaleHumansMaleParentsPersonality TestsPostoperative ComplicationsPostoperative PeriodProspective StudiesRecovery RoomRisk AssessmentSurveys and QuestionnairesTemperamentTime FactorsConceptsPost-Hospital Behavior QuestionnaireEmergence deliriumMaladaptive behavioral changesPreoperative anxietyState anxiety scoresPostoperative maladaptive behavioral changesBehavioral changesAnxiety scoresPostoperative day 1Postanesthesia care unitPostoperative behavioral changesYale Preoperative Anxiety ScalePostoperative maladaptive behaviorsCare unitGeneral anesthesiaPostoperative phenomenonSevoflurane/Odds ratioDeliriumDay 1Clinical phenomenaSurgeryRegression analysisEmergence statusChildrenNeonatal hypoxia suppresses oligodendrocyte Nogo-A and increases axonal sprouting in a rodent model for human prematurity
Weiss J, Takizawa B, McGee A, Stewart WB, Zhang H, Ment L, Schwartz M, Strittmatter S. Neonatal hypoxia suppresses oligodendrocyte Nogo-A and increases axonal sprouting in a rodent model for human prematurity. Experimental Neurology 2004, 189: 141-149. PMID: 15296844, DOI: 10.1016/j.expneurol.2004.05.018.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAnimalsAnimals, NewbornAxonsBehavior, AnimalBiotinCentral Nervous SystemDextransDisease Models, AnimalExploratory BehaviorHumansHypoxia, BrainImmunoblottingImmunohistochemistryInfant, NewbornInfant, PrematureMiceMice, Inbred C57BLMyelin Basic ProteinMyelin ProteinsMyelin-Associated GlycoproteinNogo ProteinsOligodendrogliaReceptors, Cell SurfaceTime FactorsConceptsChronic sublethal hypoxiaPeriventricular leukomalaciaMyelin associated glycoproteinCorticospinal tractWhite matterLow birth weight infantsCerebral white matter volumeBirth weight infantsLow birth weightAnterograde axonal tracingPeriventricular white matterPremature human infantsCNS white matterWhite matter volumeHypoxia-induced reductionWeight infantsAxonal sproutingCerebral ventriculomegalyCorticofugal fibersLocomotor hyperactivityNeonatal hypoxiaPersistent abnormalitiesMotor cortexBirth weightHuman prematurity
2003
Basal Ganglia Volumes in Patients With Gilles de la Tourette Syndrome
Peterson BS, Thomas P, Kane MJ, Scahill L, Zhang H, Bronen R, King RA, Leckman JF, Staib L. Basal Ganglia Volumes in Patients With Gilles de la Tourette Syndrome. JAMA Psychiatry 2003, 60: 415-424. PMID: 12695320, DOI: 10.1001/archpsyc.60.4.415.Peer-Reviewed Original ResearchConceptsBasal ganglia volumesBasal gangliaCaudate nucleus volumeTourette syndromeGanglia volumesObsessive-compulsive disorderLenticular nucleus volumesTic symptomsNucleus volumeGilles dePathophysiology of TSPrior neuroleptic exposureHealthy control subjectsSeverity of ticsComorbid obsessive-compulsive disorderGreat clinical relevanceAttention-deficit/hyperactivity disorder (ADHD) symptomsHyperactivity disorder symptomsRepeated-measures analysisNeuroleptic exposureControl subjectsFunctional disturbancesTrait abnormalityClinical relevanceGanglia
1996
Risk Factors for Presenting Problems in Child Psychiatric Emergencies
PETERSON B, ZHANG H, SANTA LUCIA R, KING R, LEWIS M. Risk Factors for Presenting Problems in Child Psychiatric Emergencies. Journal Of The American Academy Of Child & Adolescent Psychiatry 1996, 35: 1162-1173. PMID: 8824060, DOI: 10.1097/00004583-199609000-00014.Peer-Reviewed Original ResearchConceptsRisk factorsEmergency roomPsychiatric emergenciesSuicide attemptsChild psychiatric emergenciesIndependent risk factorEmergency room visitsSimilar risk factorsHospitalization of childrenDemographic risk factorsYears of agePsychiatric emergency roomHospital emergency roomSubset of childrenStrength of associationAggressive presentationInitial visitMale sexRoom visitsSuicidal ideatorsSuicidal ideationYounger ageFuture suicidalityPsychiatric subjectsHospitalization