2018
Subtype Classification and Heterogeneous Prognosis Model Construction in Precision Medicine
You N, He S, Wang X, Zhu J, Zhang H. Subtype Classification and Heterogeneous Prognosis Model Construction in Precision Medicine. Biometrics 2018, 74: 814-822. PMID: 29359319, DOI: 10.1111/biom.12843.Peer-Reviewed Original ResearchConceptsRegularization regressionVariable selectionHigh-dimensional predictorsNecessary statistical methodsVariable selection methodsExpectation-maximization algorithmOracle propertyPenalty parameterSemiparametric modelStatistical methodsParametric modelNumerical calculationsProper choiceModel constructionSelection methodGene expression datasetsModelEstimatorSubtype-specific risk factorsRegularizerSurvival probabilityHigh-throughput technologiesExpression datasetsAlgorithmSimulations
2012
Genetic Association Test for Multiple Traits at Gene Level
Guo X, Liu Z, Wang X, Zhang H. Genetic Association Test for Multiple Traits at Gene Level. Genetic Epidemiology 2012, 37: 122-129. PMID: 23032486, PMCID: PMC3524409, DOI: 10.1002/gepi.21688.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesMultiple traitsGene levelSingle nucleotide polymorphismsGenetic association testsCommon genesAssociation studiesAssociation TestNucleotide polymorphismsTraitsStudy of AddictionComplex diseasesBiological mechanismsDisease of interestAssociation informationGenesGeneticsSuch studiesStrong evidencePolymorphismPrevious findingsLevelsMultiscale Adaptive Marginal Analysis of Longitudinal Neuroimaging Data with Time-Varying Covariates
Skup M, Zhu H, Zhang H. Multiscale Adaptive Marginal Analysis of Longitudinal Neuroimaging Data with Time-Varying Covariates. Biometrics 2012, 68: 1083-1092. PMID: 22551084, PMCID: PMC3767131, DOI: 10.1111/j.1541-0420.2012.01767.x.Peer-Reviewed Original Research
2011
Statistical Inference in Mixed Models and Analysis of Twin and Family Data
Wang X, Guo X, He M, Zhang H. Statistical Inference in Mixed Models and Analysis of Twin and Family Data. Biometrics 2011, 67: 987-995. PMID: 21306354, PMCID: PMC3129472, DOI: 10.1111/j.1541-0420.2010.01548.x.Peer-Reviewed Original ResearchConceptsStandard regularity conditionsStatistical inferenceAsymptotic distributionRegularity conditionsSufficient conditionsCholesky decompositionLikelihood ratio testComputational softwareLinear modelAdvanced theoryFamily data analysisImportant exampleRatio testFamily dataKey ideaPrecise estimatesMixed-effects modelsTheoryMixed effects modelsData setsIdentifiabilityModelEstimatesMixed modelsGeneral linear model
2009
Analysis of Twin Data Using SAS
Feng R, Zhou G, Zhang M, Zhang H. Analysis of Twin Data Using SAS. Biometrics 2009, 65: 584-589. PMID: 18647295, PMCID: PMC2700843, DOI: 10.1111/j.1541-0420.2008.01098.x.Peer-Reviewed Original Research
2007
A genomic imprinting test for ordinal traits in pedigree data
Feng R, Zhang H. A genomic imprinting test for ordinal traits in pedigree data. Genetic Epidemiology 2007, 32: 132-142. PMID: 17922481, DOI: 10.1002/gepi.20270.Peer-Reviewed Original ResearchMeSH KeywordsAlcoholismGenetic Predisposition to DiseaseGenomic ImprintingHumansModels, GeneticModels, StatisticalPedigreeConceptsComplex genetic basisOrdinal traitsIdentical nucleotide sequencesGenomic imprintingNumerous common diseasesNovel lociNucleotide sequenceComplex inheritanceGenetic basisChromosome 3Non-genetic covariatesHuman disordersLinkage analysisHuman diseasesGenetics of AlcoholismChromosome 18Continuous traitsTraitsPedigree dataBinary traitsOrigin effectsImprinting testLociStrong signalImprintingA score test for linkage analysis of ordinal traits based on IBD sharing
Feng R, Zhang H. A score test for linkage analysis of ordinal traits based on IBD sharing. Biostatistics 2007, 9: 114-127. PMID: 17519391, DOI: 10.1093/biostatistics/kxm016.Peer-Reviewed Original Research
2006
Family‐based association tests for ordinal traits adjusting for covariates
Wang X, Ye Y, Zhang H. Family‐based association tests for ordinal traits adjusting for covariates. Genetic Epidemiology 2006, 30: 728-736. PMID: 17086513, DOI: 10.1002/gepi.20184.Peer-Reviewed Original ResearchLinkage analysis of longitudinal data and design consideration
Zhang H, Zhong X. Linkage analysis of longitudinal data and design consideration. BMC Genomic Data 2006, 7: 37. PMID: 16768806, PMCID: PMC1550417, DOI: 10.1186/1471-2156-7-37.Peer-Reviewed Original ResearchA statistical framework for the classification of tensor morphologies in diffusion tensor images
Zhu H, Xu D, Raz A, Hao X, Zhang H, Kangarlu A, Bansal R, Peterson BS. A statistical framework for the classification of tensor morphologies in diffusion tensor images. Magnetic Resonance Imaging 2006, 24: 569-582. PMID: 16735178, PMCID: PMC2367261, DOI: 10.1016/j.mri.2006.01.004.Peer-Reviewed Original Research
2004
Correcting the loss of cell-cycle synchrony in clustering analysis of microarray data using weights
Duan F, Zhang H. Correcting the loss of cell-cycle synchrony in clustering analysis of microarray data using weights. Bioinformatics 2004, 20: 1766-1771. PMID: 15166015, DOI: 10.1093/bioinformatics/bth169.Peer-Reviewed Original ResearchAlgorithmsBiological ClocksCell CycleCluster AnalysisGene Expression ProfilingGene Expression Regulation, FungalModels, GeneticModels, StatisticalOligonucleotide Array Sequence AnalysisPattern Recognition, AutomatedReproducibility of ResultsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSensitivity and SpecificityTime FactorsMixed effects multivariate adaptive splines model for the analysis of longitudinal and growth curve data
Zhang H. Mixed effects multivariate adaptive splines model for the analysis of longitudinal and growth curve data. Statistical Methods In Medical Research 2004, 13: 63-82. PMID: 14746441, DOI: 10.1191/0962280204sm353ra.Peer-Reviewed Original ResearchMeSH KeywordsBiomedical ResearchLongitudinal StudiesModels, StatisticalMultivariate AnalysisStatistics, NonparametricUnited States
2000
Use of classification trees for association studies
Zhang H, Bonney G. Use of classification trees for association studies. Genetic Epidemiology 2000, 19: 323-332. PMID: 11108642, DOI: 10.1002/1098-2272(200012)19:4<323::aid-gepi4>3.0.co;2-5.Peer-Reviewed Original ResearchA Frailty Model of Segregation Analysis: Understanding the Familial Transmission of Alcoholism
Zhang H, Merikangas K. A Frailty Model of Segregation Analysis: Understanding the Familial Transmission of Alcoholism. Biometrics 2000, 56: 815-823. PMID: 10985221, DOI: 10.1111/j.0006-341x.2000.00815.x.Peer-Reviewed Original Research
1999
Binary Regression for Risks in Excess of Subject-Specific Thresholds
Zhang H, Zelterman D. Binary Regression for Risks in Excess of Subject-Specific Thresholds. Biometrics 1999, 55: 1247-1251. PMID: 11315077, DOI: 10.1111/j.0006-341x.1999.01247.x.Peer-Reviewed Original ResearchAnalysis of Infant Growth Curves Using Multivariate Adaptive Splines
Zhang H. Analysis of Infant Growth Curves Using Multivariate Adaptive Splines. Biometrics 1999, 55: 452-459. PMID: 11318199, DOI: 10.1111/j.0006-341x.1999.00452.x.Peer-Reviewed Original Research
1996
Mapping quantitative trait loci with extreme discordant sib pairs: sampling considerations.
Risch N, Zhang H. Mapping quantitative trait loci with extreme discordant sib pairs: sampling considerations. American Journal Of Human Genetics 1996, 58: 836-43. PMID: 8644748, PMCID: PMC1914664.Peer-Reviewed Original Research
1995
Extreme Discordant Sib Pairs for Mapping Quantitative Trait Loci in Humans
Risch N, Zhang H. Extreme Discordant Sib Pairs for Mapping Quantitative Trait Loci in Humans. Science 1995, 268: 1584-1589. PMID: 7777857, DOI: 10.1126/science.7777857.Peer-Reviewed Original Research