2013
Candidate Gene Analysis: Severe Intraventricular Hemorrhage in Inborn Preterm Neonates
Ådén U, Lin A, Carlo W, Leviton A, Murray JC, Hallman M, Lifton RP, Zhang H, Ment LR, Group G. Candidate Gene Analysis: Severe Intraventricular Hemorrhage in Inborn Preterm Neonates. The Journal Of Pediatrics 2013, 163: 1503-1506.e1. PMID: 23896193, PMCID: PMC3812267, DOI: 10.1016/j.jpeds.2013.06.025.Peer-Reviewed Original ResearchConceptsInborn preterm neonatesIntraventricular hemorrhagePreterm neonatesSevere intraventricular hemorrhageCases of IVHAntenatal steroidsGrade 3Methylenetetrahydrofolate reductaseComplex etiologyHemorrhageNeonates
2007
Polymorphisms of one-carbon-metabolizing genes and risk of breast cancer in a population-based study
Xu X, Gammon M, Zhang H, Wetmur J, Rao M, Teitelbaum S, Britton J, Neugut A, Santella R, Chen J. Polymorphisms of one-carbon-metabolizing genes and risk of breast cancer in a population-based study. Carcinogenesis 2007, 28: 1504-1509. PMID: 17372271, DOI: 10.1093/carcin/bgm061.Peer-Reviewed Original ResearchConceptsOne-carbon metabolismRate-limiting enzymeThymidylate synthaseRate-limiting genesOne-carbon pathwayDNA methylationEpigenetic processesSame pathwayGenesMethylenetetrahydrofolate reductaseDNA synthesisEnzymePathwayCritical rolePolymorphismSame populationCancer etiologyPopulation-based Long Island Breast Cancer Study ProjectMetabolismFunctional polymorphismsRepeat alleleMethylationReductaseAllelesSynthase