2020
Margin negative resection and pathologic downstaging with multiagent chemotherapy with or without radiotherapy in patients with localized pancreas cancer: A national cancer database analysis
Miccio JA, Talcott WJ, Patel T, Park HS, Cecchini M, Salem RR, Khan SA, Stein S, Kortmansky JS, Lacy J, Narang A, Herman J, Jabbour SK, Hallemeier CL, Johung K, Jethwa KR. Margin negative resection and pathologic downstaging with multiagent chemotherapy with or without radiotherapy in patients with localized pancreas cancer: A national cancer database analysis. Clinical And Translational Radiation Oncology 2020, 27: 15-23. PMID: 33392398, PMCID: PMC7772693, DOI: 10.1016/j.ctro.2020.12.003.Peer-Reviewed Original ResearchPancreatic ductal adenocarcinomaCT3-4 diseaseMargin-negative resectionR0 resectionNon-metastatic pancreatic ductal adenocarcinomaLocalized Pancreatic Ductal AdenocarcinomaNational Cancer Database AnalysisPre-operative RTMulti-agent chemotherapyNational Cancer DatabasePathologic complete responsePre-operative radiotherapyKaplan-Meier methodCox regression analysisMultivariable associateMultiagent chemotherapyNegative resectionPathologic responseComplete responseMeier methodCurative treatmentPancreas cancerFemale sexCancer DatabaseDuctal adenocarcinoma
2016
The effect of microscopic margin status on survival in adult retroperitoneal soft tissue sarcomas
Stahl JM, Corso CD, Park HS, An Y, Rutter CE, Han D, Roberts KB. The effect of microscopic margin status on survival in adult retroperitoneal soft tissue sarcomas. European Journal Of Surgical Oncology 2016, 43: 168-174. PMID: 27335080, DOI: 10.1016/j.ejso.2016.05.031.Peer-Reviewed Original ResearchConceptsSoft tissue sarcomasOverall survivalR1 resectionR0 resectionMargin statusNational Cancer Data BaseRetroperitoneal soft tissue sarcomaCox proportional hazards regressionPropensity scoreMultivariable logistic regression modelMedian overall survivalMicroscopic margin statusPre-operative RTReceipt of RTUnderwent R0 resectionSuperior overall survivalSmaller tumor sizeLow tumor gradeProportional hazards regressionLog-rank testRetroperitoneal soft tissueLogistic regression modelsLiposarcoma histologyR1 patientsRadiotherapy receipt
2015
Addition of radiotherapy to adjuvant chemotherapy is associated with improved overall survival in resected pancreatic adenocarcinoma: An analysis of the National Cancer Data Base
Rutter CE, Park HS, Corso CD, Lester-Coll NH, Mancini BR, Yeboa DN, Johung KL. Addition of radiotherapy to adjuvant chemotherapy is associated with improved overall survival in resected pancreatic adenocarcinoma: An analysis of the National Cancer Data Base. Cancer 2015, 121: 4141-4149. PMID: 26280559, DOI: 10.1002/cncr.29652.Peer-Reviewed Original ResearchConceptsImproved overall survivalNational Cancer Data BaseOverall survivalPancreatic adenocarcinomaAdjuvant chemotherapyR0 resectionR1 resectionPN1 diseaseNational cohortSubset analysisPropensity scoreAddition of radiotherapyMedian radiotherapy doseOutcome of chemotherapyLarge national cohortPT1-3N0CRT groupClinicopathologic characteristicsCRT patientsRandomized comparisonCox regressionRadiotherapy doseOptimal treatmentPancreatic cancerUnivariate analysis