2023
Serotonin transporter availability in physically aggressive personality disordered patients: associations with trait and state aggression, and response to fluoxetine
Rosell D, Slifstein M, Thompson J, Xu X, Perez-Rodriguez M, McClure M, Hazlett E, New A, Nabulsi N, Huang Y, Carson R, Siever L, Abi-Dargham A, Koenigsberg H. Serotonin transporter availability in physically aggressive personality disordered patients: associations with trait and state aggression, and response to fluoxetine. Psychopharmacology 2023, 240: 361-371. PMID: 36640190, DOI: 10.1007/s00213-022-06306-2.Peer-Reviewed Original ResearchConceptsAnterior cingulate cortexAnti-aggressive effectsIED patientsPositron emission tomographyVentral striatumTransporter availabilityChildhood traumaSerotonin transporter availabilityRational treatment selectionIntermittent explosive disorderFluoxetine 20Fluoxetine treatmentSerotonergic abnormalitiesHealthy comparison participantsTreatment selectionRisk individualsObjectivesThe aimPatientsCingulate cortexExplosive disorderEmission tomographyImpulsive aggressionNovel therapeuticsFluoxetineNeuroanatomical basis
1998
Chapter 44 Characterization of the Radiolabeled Metabolites of [18F]Altanserin Implications for Kinetic Modeling
Lopresti B, Holt D, Mason N, Huang Y, Ruszkiewicz J, Perevuznik J, Price J, Smith G, Davis J, Mathis C. Chapter 44 Characterization of the Radiolabeled Metabolites of [18F]Altanserin Implications for Kinetic Modeling. 1998, 293-298. DOI: 10.1016/b978-012161340-2/50046-9.Peer-Reviewed Original ResearchVivo positron emission tomography (PET) imaging studiesPositron emission tomography (PET) imaging studiesTomography Imaging StudyPostmortem brain studiesSerotonergic abnormalitiesSerotonergic dysfunctionMajor depressionRadiolabeled metabolitesTherapeutic efficacyAlzheimer's diseaseImaging studiesNeurodegenerative disordersPET studiesReceptorsBrain studiesVivo propertiesDiseaseRadioligandDisordersDysfunctionAltanserinAbnormalitiesNonspecific bindingSchizophrenia