2022
Synthesis and characterization of the two enantiomers of a chiral sigma-1 receptor radioligand: (S)-(+)- and (R)-(-)-[18F]FBFP
Wang T, Zhang Y, Zhang X, Chen L, Zheng M, Zhang J, Brust P, Deuther-Conrad W, Huang Y, Jia H. Synthesis and characterization of the two enantiomers of a chiral sigma-1 receptor radioligand: (S)-(+)- and (R)-(-)-[18F]FBFP. Chinese Chemical Letters 2022, 33: 3543-3548. DOI: 10.1016/j.cclet.2022.03.099.Peer-Reviewed Original ResearchIodonium ylide precursorsMicro-positron emission tomographyHigh brain uptakeBrain uptakeICR miceBrain kineticsBlood ratioReceptor radiotracerReceptor radioligandEmission tomographyFurther evaluationFast clearanceComparable high affinityReceptorsBrainUnlabeled compoundsVivo stabilitySuperior imaging propertiesMolar activityHigh affinityAgonistsAntagonistRatsMiceRadioligand
1999
Pet imaging of serotonin 1A receptor binding in depression
Drevets W, Frank E, Price J, Kupfer D, Holt D, Greer P, Huang Y, Gautier C, Mathis C. Pet imaging of serotonin 1A receptor binding in depression. Biological Psychiatry 1999, 46: 1375-1387. PMID: 10578452, DOI: 10.1016/s0006-3223(99)00189-4.Peer-Reviewed Original ResearchConceptsFamilial mood disordersReceptor BPPostmortem studiesMood disordersMesiotemporal cortexMidbrain rapheSerotonin 1A receptor systemBrain regionsPET imagingPrevious postmortem studiesSerotonin 1A receptorMultiple brain regionsHistopathological changesHealthy controlsBP valuesMajor depressionDepressed phasePostcentral gyrusClinical conditionsOccipital cortexBipolar relativesBipolar depressivesReceptor radioligandDepressed subjectsNormal baseline