Stereoconservative synthesis of the enantiomerically pure precursors of [11C](+)‐McN 5652 and [11C](−)‐McN 5652
Huang Y, Mahmood K, Simpson N, Mason N, Mathis C. Stereoconservative synthesis of the enantiomerically pure precursors of [11C](+)‐McN 5652 and [11C](−)‐McN 5652. Journal Of Labelled Compounds And Radiopharmaceuticals 1998, 41: 9-17. DOI: 10.1002/(sici)1099-1344(199801)41:1<9::aid-jlcr47>3.0.co;2-8.Peer-Reviewed Original ResearchBenzoyl thioesterTartrate saltFinal productOne-pot deprotectionSynthetic routeConvenient precursorsReaction sequenceSynthesis yieldDetectable isomerizationPurification procedureThioestersThioethersKey stepSubsequent formationSpecific activityCi/High specific activitySaltHPLC analysisPrecursorsRadiochemical purityS-methylationDeprotectionIsomerizationRadiosynthesis