1999
Differential regulation of NHE isoforms by sodium depletion in proximal and distal segments of rat colon
Ikuma M, Kashgarian M, Binder H, Rajendran V. Differential regulation of NHE isoforms by sodium depletion in proximal and distal segments of rat colon. American Journal Of Physiology 1999, 276: g539-g549. PMID: 9950829, DOI: 10.1152/ajpgi.1999.276.2.g539.Peer-Reviewed Original ResearchConceptsDietary sodium depletionSodium depletionDistal colonRat colonProtein expressionMRNA abundanceBlot analysisDose-dependent inhibitorApical membrane vesiclesElectroneutral NaCl absorptionWestern blot analysisDifferential regulationNormal ratsProximal colonHOE 694Multiple diverse effectsColonDistal segmentsNaCl absorptionNHE isoformsExchange activityExchanger isoformsNorthern blot analysisDifferential effectsPretranslational level
1990
Aldosterone and glucocorticoid receptor-specific agonists regulate ion transport in rat proximal colon
Turnamian S, Binder H. Aldosterone and glucocorticoid receptor-specific agonists regulate ion transport in rat proximal colon. American Journal Of Physiology 1990, 258: g492-g498. PMID: 2138421, DOI: 10.1152/ajpgi.1990.258.3.g492.Peer-Reviewed Original ResearchConceptsDietary sodium depletionBody wt-1RU 28362Receptor-specific agonistsSodium depletionPotassium secretionProximal colonDay 1Glucocorticoid receptorWT-1Cl absorptionAdministration of spironolactoneActive potassium secretionRat proximal colonSecondary hyperaldosteronismContinuous infusionAldosteroneGlucocorticoid agonistAgonistsElectrolyte transportSecretionStimulationSignificant increaseInfusionColon
1986
Role of Aldosterone in the Regulation of Sodium and Chloride Transport in the Distal Colon of Sodium-Depleted Rats
Halevy J, Budinger M, Hayslett J, Binder H. Role of Aldosterone in the Regulation of Sodium and Chloride Transport in the Distal Colon of Sodium-Depleted Rats. Gastroenterology 1986, 91: 1227-1233. PMID: 3758615, DOI: 10.1016/s0016-5085(86)80021-x.Peer-Reviewed Original ResearchConceptsElectroneutral sodium chloride absorptionElectrogenic sodium absorptionSodium chloride absorptionRole of aldosteroneSodium-depleted animalsSodium absorptionChloride absorptionAldosterone infusionDistal colonPotassium secretionAmiloride-sensitive sodium absorptionContinuous aldosterone infusionDietary sodium depletionDistal colonic mucosaElevated aldosterone levelsActive potassium secretionRat distal colonAddition of amilorideRegulation of sodiumVoltage-clamp conditionsAldosterone levelsTime-dependent mannerSodium depletionColonic mucosaAldosterone