1995
Fluid absorption in isolated perfused colonic crypts.
Singh S, Binder H, Boron W, Geibel J. Fluid absorption in isolated perfused colonic crypts. Journal Of Clinical Investigation 1995, 96: 2373-2379. PMID: 7593625, PMCID: PMC185889, DOI: 10.1172/jci118294.Peer-Reviewed Original ResearchConceptsCrypt cellsNM vasoactive intestinal peptideFluid absorptionLarge intestinal functionColonic cryptsVasoactive intestinal peptideLamina propria cellsNet fluid secretionRat distal colonNet fluid absorptionDibutyryl cyclic AMPIntestinal peptideDistal colonIntestinal functionLamina propriaPathophysiological paradigmCrypt preparationMM acetylcholineBasal stateNeurohumoral agonistsFluid secretionCellular elementsEpithelial cellsIntestinal cryptsCrypts
1975
Glucagon secretion in acute and chronic pancreatitis.
Donowitz M, Hendler R, Spiro H, Binder H, Felig P. Glucagon secretion in acute and chronic pancreatitis. Annals Of Internal Medicine 1975, 83: 778-81. PMID: 1200523, DOI: 10.7326/0003-4819-83-6-778.Peer-Reviewed Original ResearchConceptsAcute pancreatitisPancreatic insufficiencyAlpha-cell responsivenessChronic pancreatic insufficiencyBasal glucagon levelsPancreatic glucagon concentrationsInfusion of alaninePrevious pancreatitisGlucagon responseAcute episodeGlucagon levelsGlucagon secretionChronic pancreatitisPlasma glucagonGlucagon concentrationsInitial episodeHealthy controlsPancreatitisCell responsivenessPatientsBasal statePrevious attacksSensitive indexInitial attackInsufficiency