2023
Alcohol-mediated renal denervation in patients with hypertension in the absence of antihypertensive medications.
Pathak A, Rudolph U, Saxena M, Zeller T, Müller-Ehmsen J, Lipsic E, Schmieder R, Sievert H, Halbach M, Sharif F, Parise H, Fischell T, Weber M, Kandzari D, Mahfoud F. Alcohol-mediated renal denervation in patients with hypertension in the absence of antihypertensive medications. EuroIntervention 2023, 19: 602-611. PMID: 37427416, PMCID: PMC10493775, DOI: 10.4244/eij-d-23-00088.Peer-Reviewed Original ResearchConceptsSystolic blood pressureRenal denervationBlood pressureAntihypertensive medicationsRDN groupMedication burdenMean office blood pressureOffice systolic blood pressureSystolic BP 140Office blood pressurePrimary efficacy endpointMajor adverse eventsSystolic BP changeDiastolic blood pressureLower blood pressureRadiofrequency renal denervationLower medication burdenSignificant BP differencesMedication escalationEfficacy endpointSafety endpointAdverse eventsSham groupBP changesMedication washout
2022
Impact of drug adherence on blood pressure response to alcohol-mediated renal denervation
Persu A, Maes F, Toennes S, Ritscher S, Georges C, Wallemacq P, Haratani N, Parise H, Fischell T, Lauder L, Mahfoud F. Impact of drug adherence on blood pressure response to alcohol-mediated renal denervation. Blood Pressure 2022, 31: 109-117. PMID: 35575248, DOI: 10.1080/08037051.2022.2074367.Peer-Reviewed Original ResearchConceptsRenal denervationDrug adherenceBlood pressure changesNon-adherent patientsPoor drug adherenceTreatment-resistant hypertensionSham-controlled trialBlood pressure responseSystolic blood pressureUncontrolled hypertensionAntihypertensive medicationsResistant hypertensionSuch patientsBlood pressureAntihypertensive drugsDenervationMean 24Partial adherencePatientsFull adherenceUrinary detectionHypertensionPressure changesLiquid chromatography-tandem mass spectrometryAdherence
2007
Pulse Pressure and Risk of New-Onset Atrial Fibrillation
Mitchell G, Vasan R, Keyes M, Parise H, Wang T, Larson M, D’Agostino R, Kannel W, Levy D, Benjamin E. Pulse Pressure and Risk of New-Onset Atrial Fibrillation. JAMA 2007, 297: 709-715. PMID: 17312290, DOI: 10.1001/jama.297.7.709.Peer-Reviewed Original ResearchConceptsIncident atrial fibrillationMean arterial pressureAtrial fibrillationPulse pressureRisk factorsArterial pressureCommunity-based observational cohortNew-onset atrial fibrillationIncidence of AFAF incidence ratesClinical risk factorsModifiable risk factorsVentricular fractional shorteningFramingham Heart Study participantsImportant risk factorCommunity-based sampleAtrial dimensionObservational cohortAortic stiffnessConsiderable morbidityFractional shorteningSystolic pressureAF riskDiastolic pressureVentricular mass
2005
Cross-Sectional Relations of Peripheral Microvascular Function, Cardiovascular Disease Risk Factors, and Aortic Stiffness
Mitchell G, Vita J, Larson M, Parise H, Keyes M, Warner E, Vasan R, Levy D, Benjamin E. Cross-Sectional Relations of Peripheral Microvascular Function, Cardiovascular Disease Risk Factors, and Aortic Stiffness. Circulation 2005, 112: 3722-3728. PMID: 16330686, DOI: 10.1161/circulationaha.105.551168.Peer-Reviewed Original ResearchConceptsCarotid-femoral pulse wave velocityCardiovascular disease risk factorsDisease risk factorsBrachial pulse pressureMean arterial pressureAortic stiffnessAortic wall stiffnessRisk factorsArterial pressurePulse pressureBlood flowConventional cardiovascular disease risk factorsHyperemic forearm blood flowRisk factor-adjusted modelsFramingham Heart Study Offspring CohortAbnormal aortic stiffnessForearm blood flowBrachial artery diameterPeripheral microvascular functionForward pressure wave amplitudePulse wave velocitySmall artery structureHigh-resolution ultrasoundWall stiffnessMicrovascular reactivity
2004
Changes in Arterial Stiffness and Wave Reflection With Advancing Age in Healthy Men and Women
Mitchell G, Parise H, Benjamin E, Larson M, Keyes M, Vita J, Vasan R, Levy D. Changes in Arterial Stiffness and Wave Reflection With Advancing Age in Healthy Men and Women. Hypertension 2004, 43: 1239-1245. PMID: 15123572, DOI: 10.1161/01.hyp.0000128420.01881.aa.Peer-Reviewed Original ResearchConceptsPulse wave velocityCarotid-femoral pulse wave velocityArterial stiffness gradientArterial stiffnessPulse pressureHigher carotid-femoral pulse wave velocityElevated central pulse pressureHigher mean arterial pressureCardiovascular disease risk factorsPeripheral pulse wave velocityFramingham Heart Study Offspring CohortClinical cardiovascular diseaseMean arterial pressurePeripheral arterial stiffnessCentral pulse pressureDisease risk factorsMultivariable linear regression modelsAge 50 yearsAge-related increaseArterial tonometryAortic stiffnessArterial pressureAugmentation indexHealthy menUnfavorable prognosis