Parental Atrial Fibrillation as a Risk Factor for Atrial Fibrillation in Offspring
Fox C, Parise H, D'Agostino R, Lloyd-Jones D, Vasan R, Wang T, Levy D, Wolf P, Benjamin E. Parental Atrial Fibrillation as a Risk Factor for Atrial Fibrillation in Offspring. JAMA 2004, 291: 2851-2855. PMID: 15199036, DOI: 10.1001/jama.291.23.2851.Peer-Reviewed Original ResearchConceptsAtrial fibrillationOffspring participantsNew-onset atrial fibrillationPopulation-based epidemiologic studyAntecedent myocardial infarctionCommon cardiac dysrhythmiaProspective cohort studyYears of ageFramingham Heart StudyFamilial atrial fibrillationCohort studyHeart failureCardiac dysrhythmiasMyocardial infarctionOriginal cohortRisk factorsEpidemiologic studiesRare caseHeart StudyGenetic susceptibilityFibrillationUnselected individualsGenetic factorsDysrhythmiasFuture riskMitral annular calcification is a predictor for incident atrial fibrillation
Fox C, Parise H, Vasan R, Levy D, O’Donnell C, D’Agostino R, Plehn J, Benjamin E. Mitral annular calcification is a predictor for incident atrial fibrillation. Atherosclerosis 2004, 173: 291-294. PMID: 15064104, DOI: 10.1016/j.atherosclerosis.2003.12.018.Peer-Reviewed Original ResearchMeSH KeywordsAge DistributionAgedAged, 80 and overAtrial FibrillationCalcinosisCohort StudiesComorbidityEchocardiography, DopplerElectrocardiographyFemaleFollow-Up StudiesHumansIncidenceMaleMiddle AgedMitral Valve StenosisProbabilityProportional Hazards ModelsRetrospective StudiesRisk AssessmentSeverity of Illness IndexSex DistributionConceptsMitral annular calcificationIncident atrial fibrillationAtrial fibrillationAnnular calcificationAdverse cardiovascular disease outcomesSex-adjusted incidence ratesRisk of AFLeft atrial sizeMultivariable-adjusted analysesCardiac valvular calcificationCardiovascular disease outcomesCommunity-based cohortM-mode echocardiographyProportional hazards modelLong-term riskFramingham Heart StudyIncident AFHazard ratioAtrial enlargementAtrial sizeEchocardiographic assessmentValvular calcificationOriginal cohortProspective dataIncidence rate