2023
Alcohol-mediated renal denervation in patients with hypertension in the absence of antihypertensive medications.
Pathak A, Rudolph U, Saxena M, Zeller T, Müller-Ehmsen J, Lipsic E, Schmieder R, Sievert H, Halbach M, Sharif F, Parise H, Fischell T, Weber M, Kandzari D, Mahfoud F. Alcohol-mediated renal denervation in patients with hypertension in the absence of antihypertensive medications. EuroIntervention 2023, 19: 602-611. PMID: 37427416, PMCID: PMC10493775, DOI: 10.4244/eij-d-23-00088.Peer-Reviewed Original ResearchConceptsSystolic blood pressureRenal denervationBlood pressureAntihypertensive medicationsRDN groupMedication burdenMean office blood pressureOffice systolic blood pressureSystolic BP 140Office blood pressurePrimary efficacy endpointMajor adverse eventsSystolic BP changeDiastolic blood pressureLower blood pressureRadiofrequency renal denervationLower medication burdenSignificant BP differencesMedication escalationEfficacy endpointSafety endpointAdverse eventsSham groupBP changesMedication washout
2018
CHEMICAL RENAL DENERVATION WITH ALCOHOL – LONG TERM RESULTS FROM THE PEREGRINE POST-MARKET STUDY
Persu A, Renkin J, Hochul M, Wojakowski W, Böhm M, Mahfoud F, Schmieder R, van der Giet M, de Bucourt M, Zirlik A, Neuzil P, Haratani N, Parise H, Fischell T, Bertog S, Sievert K, Sievert H. CHEMICAL RENAL DENERVATION WITH ALCOHOL – LONG TERM RESULTS FROM THE PEREGRINE POST-MARKET STUDY. Journal Of Hypertension 2018, 36: e123. DOI: 10.1097/01.hjh.0000539319.18701.45.Peer-Reviewed Original ResearchSystolic office blood pressureChemical renal denervationResistant hypertensionPost-market studyRenal denervationVascular access site complicationsWhite-coat resistant hypertensionMajor efficacy endpointsMulticenter European trialSignificant BP reductionOffice blood pressureRenal artery dissectionTransient ischemic attackAccess site complicationsAnti-hypertensive medicationsMean procedure timeMajor safety endpointsML of alcoholAnatomical eligibilityAntihypertensive medicationsBP reductionEligible patientsIschemic attackOpen labelRenal events