2024
Effect of Alcohol-Mediated Renal Denervation on Blood Pressure in the Presence of Antihypertensive Medications: Primary Results From the TARGET BP I Randomized Clinical Trial
Kandzari D, Weber M, Pathak A, Zidar J, Saxena M, David S, Schmieder R, Janas A, Langer C, Persu A, Mendelsohn F, Ameloot K, Foster M, Fischell T, Parise H, Mahfoud F. Effect of Alcohol-Mediated Renal Denervation on Blood Pressure in the Presence of Antihypertensive Medications: Primary Results From the TARGET BP I Randomized Clinical Trial. Circulation 2024, 149: 1875-1884. PMID: 38587557, DOI: 10.1161/circulationaha.124.069291.Peer-Reviewed Original ResearchSystolic blood pressureOffice systolic blood pressureRenal denervationOffice diastolic BPAmbulatory systolic BPBlood pressureSham controlsPrimary endpointBetween-group differencesNo significant differenceAntihypertensive medicationsDiastolic BPSystolic BPPresence of antihypertensive medicationBaseline-adjusted changeRenal artery dissectionMonths post-procedureSignificant differenceRenal denervation groupAmbulatory systolic blood pressureNo significant between-group differencesStatistically significant reductionSignificant between-group differencesSecondary endpointsOffice BP
2020
Evaluation of Transcatheter Alcohol-Mediated Perivascular Renal Denervation to Treat Resistant Hypertension
Janas A, Król M, Hochuł M, Jochymczyk M, Hayward-Costa C, Parise H, Haratani N, Fischell T, Wojakowski W. Evaluation of Transcatheter Alcohol-Mediated Perivascular Renal Denervation to Treat Resistant Hypertension. Journal Of Clinical Medicine 2020, 9: 1881. PMID: 32560164, PMCID: PMC7356226, DOI: 10.3390/jcm9061881.Peer-Reviewed Original ResearchAmbulatory blood pressure monitoringRenal denervationResistant hypertensionOffice BPCatheter-based renal denervationBlood pressure monitoringRenal artery anatomyHypothesis-generating studyContrast computer tomographyAnti-hypertension drugsNephrologist consultationResistant HTNAdult patientsSympathetic nervesSystolic pressureHypertension treatmentRenal arteryArtery anatomyAdventitial spaceMean decreasePressure monitoringPatientsDenervationHypertensionVariable success