Alcohol-mediated renal denervation in patients with hypertension in the absence of antihypertensive medications.
Pathak A, Rudolph U, Saxena M, Zeller T, Müller-Ehmsen J, Lipsic E, Schmieder R, Sievert H, Halbach M, Sharif F, Parise H, Fischell T, Weber M, Kandzari D, Mahfoud F. Alcohol-mediated renal denervation in patients with hypertension in the absence of antihypertensive medications. EuroIntervention 2023, 19: 602-611. PMID: 37427416, PMCID: PMC10493775, DOI: 10.4244/eij-d-23-00088.Peer-Reviewed Original ResearchConceptsSystolic blood pressureRenal denervationBlood pressureAntihypertensive medicationsRDN groupMedication burdenMean office blood pressureOffice systolic blood pressureSystolic BP 140Office blood pressurePrimary efficacy endpointMajor adverse eventsSystolic BP changeDiastolic blood pressureLower blood pressureRadiofrequency renal denervationLower medication burdenSignificant BP differencesMedication escalationEfficacy endpointSafety endpointAdverse eventsSham groupBP changesMedication washoutChocolate Touch Versus Lutonix Drug-Coated Balloon for Femoropopliteal Lesions in Diabetes: The Chocolate Touch Study.
Böhme T, Zeller T, Shishehbor M, Werner M, Brodmann M, Parise H, Holden A, Lichtenberg M, Parikh S, Kashyap V, Pietras C, Tirziu D, Beschorner U, Krishnan P, Niazi K, Wali A, Lansky A. Chocolate Touch Versus Lutonix Drug-Coated Balloon for Femoropopliteal Lesions in Diabetes: The Chocolate Touch Study. Journal Of Endovascular Therapy 2023, 15266028231179589. PMID: 37314243, DOI: 10.1177/15266028231179589.Peer-Reviewed Original ResearchLutonix drug-coated balloonDrug-coated balloonsPrimary safety endpointDM statusFemoropopliteal diseaseDiabetes mellitusSafety endpointFemoropopliteal lesionsSimilar safetyHigh-risk patient populationFemoropopliteal artery lesionsIschemic rest painNon-DM patientsSymptomatic femoropopliteal lesionsPrimary efficacy endpointMajor adverse eventsTherapy of choiceDrug-Coated BalloonMajor amputationRest painEfficacy endpointPrimary patencyAdverse eventsArtery lesionsDiabetes status