2024
A smartphone app-based mindfulness intervention to enhance recovery from substance use disorders: Protocol for a pilot feasibility randomized controlled trial
Roos C, Bricker J, Kiluk B, Trull T, Bowen S, Witkiewitz K, Kober H. A smartphone app-based mindfulness intervention to enhance recovery from substance use disorders: Protocol for a pilot feasibility randomized controlled trial. Contemporary Clinical Trials Communications 2024, 41: 101338. PMID: 39233850, PMCID: PMC11372603, DOI: 10.1016/j.conctc.2024.101338.Peer-Reviewed Original ResearchTreatment-as-usualSubstance use disordersRecovery outcomesLong-term recovery outcomesFeasibility of study proceduresFeasibility randomized controlled trialMindfulness-based treatmentsUse disorderRandomized controlled trialsEcological momentary assessmentIn-personMindfulness interventionPilot trialStudy proceduresControlled trialsMomentary assessmentPublic healthEnhanced recoveryOutpatient treatmentMechanical variablesOutcomesTrialsAppsDelivery methodsIndividualsNeuromarkers in addiction: definitions, development strategies, and recent advances
Harp N, Wager T, Kober H. Neuromarkers in addiction: definitions, development strategies, and recent advances. Journal Of Neural Transmission 2024, 131: 509-523. PMID: 38630190, DOI: 10.1007/s00702-024-02766-2.Peer-Reviewed Original ResearchConceptsSubstance use disordersFeatures of substance use disordersResponse to treatmentNeurobiological basisAddiction neuroscienceIndividual treatment outcomesPsychiatric conditionsDetecting response to treatmentPsychological phenomenaNeuromarkersIndex riskSeverity of pathologyTreatment outcomesAbnormal processingAddictionPutative markerClinical practiceStable indicatorSevere pathologyAssess riskNeurosciencePathologyReview recent advancesDisordersTreatmentParameter Space and Potential for Biomarker Development in 25 Years of fMRI Drug Cue Reactivity
Network A, Sangchooli A, Zare-Bidoky M, Jouzdani A, Schacht J, Bjork J, Claus E, Prisciandaro J, Wilson S, Wüstenberg T, Potvin S, Ahmadi P, Bach P, Baldacchino A, Beck A, Brady K, Brewer J, Childress A, Courtney K, Ebrahimi M, Filbey F, Garavan H, Ghahremani D, Goldstein R, Goudriaan A, Grodin E, Hanlon C, Haugg A, Heilig M, Heinz A, Holczer A, Van Holst R, Joseph J, Juliano A, Kaufman M, Kiefer F, Zonoozi A, Kuplicki R, Leyton M, London E, Mackey S, McClernon F, Mellick W, Morley K, Noori H, Oghabian M, Oliver J, Owens M, Paulus M, Perini I, Rafei P, Ray L, Sinha R, Smolka M, Soleimani G, Spanagel R, Steele V, Tapert S, Vollstädt-Klein S, Wetherill R, Witkiewitz K, Yuan K, Zhang X, Verdejo-Garcia A, Potenza M, Janes A, Kober H, Zilverstand A, Ekhtiari H. Parameter Space and Potential for Biomarker Development in 25 Years of fMRI Drug Cue Reactivity. JAMA Psychiatry 2024, 81: 414-425. PMID: 38324323, PMCID: PMC11304510, DOI: 10.1001/jamapsychiatry.2023.5483.Peer-Reviewed Original ResearchTreatment developmentNeurobiology of drug addictionDrug cue reactivitySubstance use disordersBiomarkers of addictionCue reactivityAddictive disordersBiomarker developmentDrug addictionTreatment responseTreatment outcomesVisual cuesTask designCore aspectsAddictionClinical judgmentParticipant characteristicsDisordersOutcome predictorsClinical useMEDLINE databaseBiomarker qualificationSeveral biomarkersTranslational gapDatabase inceptionDevelopment and initial testing of mindful journey: a digital mindfulness-based intervention for promoting recovery from Substance use disorder
Roos C, Kiluk B, Carroll K, Bricker J, Mun C, Sala M, Kirouac M, Stein E, John M, Palmer R, DeBenedictis A, Frisbie J, Haeny A, Barry D, Fucito L, Bowen S, Witkiewitz K, Kober H. Development and initial testing of mindful journey: a digital mindfulness-based intervention for promoting recovery from Substance use disorder. Annals Of Medicine 2024, 56: 2315228. PMID: 38382111, PMCID: PMC10883107, DOI: 10.1080/07853890.2024.2315228.Peer-Reviewed Original ResearchConceptsSubstance use disordersMindfulness-based interventionsPhone coachingQualitative feedbackPromote recoveryEvidence of feasibilityUse disorderPhase 2Promote long-term recoveryApp featuresUnmet needsAdjunctive interventionTen adultsSmartphone appLong-term recoveryInterventionTherapy videosMindfulness practiceParticipantsOutpatient treatmentMind toolPhase 1CoachingAcceptance dimensionQuantitative ratings
2022
A neuromarker for drug and food craving distinguishes drug users from non-users
Koban L, Wager T, Kober H. A neuromarker for drug and food craving distinguishes drug users from non-users. Nature Neuroscience 2022, 26: 316-325. PMID: 36536243, DOI: 10.1038/s41593-022-01228-w.Peer-Reviewed Original ResearchConceptsFood cravingsFunctional magnetic resonance imaging studySelf-regulation strategiesCue-induced drugMagnetic resonance imaging studySelf-reported intensityResonance imaging studyFood cuesVentromedial prefrontalSubstance use disordersIntrospective accessMaladaptive behaviorsNeurobiological markersNeurobiological mechanismsParietal association areasCingulate cortexVentral striatumConvergent validityCore featuresCravingAssociation areasSubstance useNeuromarkersUse disordersClinical interventionsAssociation of Drug Cues and Craving With Drug Use and Relapse
Vafaie N, Kober H. Association of Drug Cues and Craving With Drug Use and Relapse. JAMA Psychiatry 2022, 79: 641-650. PMID: 35648415, PMCID: PMC9161117, DOI: 10.1001/jamapsychiatry.2022.1240.Peer-Reviewed Original ResearchA methodological checklist for fMRI drug cue reactivity studies: development and expert consensus
Ekhtiari H, Zare-Bidoky M, Sangchooli A, Janes AC, Kaufman MJ, Oliver JA, Prisciandaro JJ, Wüstenberg T, Anton RF, Bach P, Baldacchino A, Beck A, Bjork JM, Brewer J, Childress AR, Claus ED, Courtney KE, Ebrahimi M, Filbey FM, Ghahremani DG, Azbari PG, Goldstein RZ, Goudriaan AE, Grodin EN, Hamilton JP, Hanlon CA, Hassani-Abharian P, Heinz A, Joseph JE, Kiefer F, Zonoozi AK, Kober H, Kuplicki R, Li Q, London ED, McClernon J, Noori HR, Owens MM, Paulus MP, Perini I, Potenza M, Potvin S, Ray L, Schacht JP, Seo D, Sinha R, Smolka MN, Spanagel R, Steele VR, Stein EA, Steins-Loeber S, Tapert SF, Verdejo-Garcia A, Vollstädt-Klein S, Wetherill RR, Wilson SJ, Witkiewitz K, Yuan K, Zhang X, Zilverstand A. A methodological checklist for fMRI drug cue reactivity studies: development and expert consensus. Nature Protocols 2022, 17: 567-595. PMID: 35121856, PMCID: PMC9063851, DOI: 10.1038/s41596-021-00649-4.Peer-Reviewed Original ResearchConceptsSubstance use disordersSystematic reviewReporting of itemsMagnetic resonance imaging studyDelphi consensus methodResonance imaging studyFunctional magnetic resonance imaging studyInitial checklistCue-reactivity studiesConsensus statementSUD treatmentConsensus paperUse disordersExpert consensusImaging studiesTask-based fMRICue reactivityIncomplete reportingMethodological checklistStructured recommendationsFMRI informationClinical translationChecklistFinal checklistReview
2018
Substance-related and addictive disorders.
Suzuki S, Kober H. Substance-related and addictive disorders. 2018, 481-506. DOI: 10.1037/0000064-020.ChaptersAddictive disordersSubstance use disordersMindfulness-based therapyRisk factorsComputer-based treatment
2010
Prefrontal–striatal pathway underlies cognitive regulation of craving
Kober H, Mende-Siedlecki P, Kross EF, Weber J, Mischel W, Hart CL, Ochsner KN. Prefrontal–striatal pathway underlies cognitive regulation of craving. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 14811-14816. PMID: 20679212, PMCID: PMC2930456, DOI: 10.1073/pnas.1007779107.Peer-Reviewed Original ResearchConceptsSubstance use disordersUse disordersPrefrontal cortexVentral tegmental areaSubstance-dependent populationsMore effective treatmentsLong-term consumptionDorsolateral prefrontal cortex activityPrefrontal cortex activityCigarette smokersTegmental areaVentrolateral prefrontal cortexVentral striatum activityVentral striatal activitySubgenual cingulateEffective treatmentLateral prefrontal cortexStriatal activityVentral striatumCortex activityFunctional imagingPhysical healthStriatum activityNeural activityCortex