Plasminogen activator inhibitor types 1 and 2 in human trophoblasts. PAI-1 is an immunocytochemical marker of invading trophoblasts.
Feinberg RF, Kao LC, Haimowitz JE, Queenan JT, Wun TC, Strauss JF, Kliman HJ. Plasminogen activator inhibitor types 1 and 2 in human trophoblasts. PAI-1 is an immunocytochemical marker of invading trophoblasts. Laboratory Investigation 1989, 61: 20-6. PMID: 2473276.Peer-Reviewed Original ResearchConceptsPAI-2Plasminogen activator inhibitorSpecific plasminogen activator inhibitorPAI-1Villous syncytiotrophoblastHuman trophoblastsCytoplasmic localizationPlasminogen activatorRegulated productionPAI expressionCytoplasmic stainingCell surface stainingCultured cytotrophoblastsProminent cytoplasmic stainingIntervillous blood flowPlasminogen activator inhibitor type 1Activator inhibitor type 1Inhibitor type 1First trimesterActivatorProteolytic enzymesVascular remodelingVillous cytotrophoblastsBlood flowImmunohistochemical analysis