1997
Repeated Doses of the Perfluorocarbon FC-100 Improve Lung Function of Preterm Lambs
Moya F, Llanos A, Ríos A, Riquelme R, Moraga F, Rubio L, Salvo H, Jacobs H. Repeated Doses of the Perfluorocarbon FC-100 Improve Lung Function of Preterm Lambs. Pediatric Research 1997, 42: 893-898. PMID: 9396575, DOI: 10.1203/00006450-199712000-00028.Peer-Reviewed Original ResearchConceptsLung functionPreterm lambsInitial doseIntratracheal administrationFC-100Administration of ExosurfSurfactant-deficient animalsSynthetic surfactant ExosurfArterial blood pressureDynamic lung compliancePreterm neonatesBlood pressureLung complianceSingle doseArterial PO2Arterial PCO2Surfactant deficiencyHeart rateAdditional doseExosurfStudy periodDoseAdministrationDosesSimilar changes
1987
Thresholds for physiological effects of plasma catecholamines in fetal sheep
Padbury J, Ludlow J, Ervin M, Jacobs H, Humme J. Thresholds for physiological effects of plasma catecholamines in fetal sheep. American Journal Of Physiology 1987, 252: e530-e537. PMID: 3565562, DOI: 10.1152/ajpendo.1987.252.4.e530.Peer-Reviewed Original ResearchConceptsBlood pressurePlasma concentrationsFetal sheepPg/Plasma free fatty acidsDiastolic blood pressureSystolic blood pressurePlasma catecholamine levelsFull-term animalsInfusion of norepinephrineMinimum plasma concentrationDose-response curvePlasma catecholamine valuesInfused norepinephrineHigher peak responsesNeonatal adaptationCatecholamine levelsPlasma catecholaminesPreterm animalsFree fatty acidsGlucose levelsE concentrationsCatecholamine valuesNorepinephrineMarked increase