2023
Detection of Left Ventricular Systolic Dysfunction From Electrocardiographic Images
Sangha V, Nargesi A, Dhingra L, Khunte A, Mortazavi B, Ribeiro A, Banina E, Adeola O, Garg N, Brandt C, Miller E, Ribeiro A, Velazquez E, Giatti L, Barreto S, Foppa M, Yuan N, Ouyang D, Krumholz H, Khera R. Detection of Left Ventricular Systolic Dysfunction From Electrocardiographic Images. Circulation 2023, 148: 765-777. PMID: 37489538, PMCID: PMC10982757, DOI: 10.1161/circulationaha.122.062646.Peer-Reviewed Original ResearchMeSH KeywordsAdultElectrocardiographyHumansLongitudinal StudiesProspective StudiesVentricular Dysfunction, LeftVentricular Function, LeftConceptsLV systolic dysfunctionYale-New Haven HospitalVentricular systolic dysfunctionSystolic dysfunctionLV ejection fractionBrazilian Longitudinal StudyNew Haven HospitalEjection fractionCardiology clinicRegional hospitalLeft ventricular systolic dysfunctionCedars-Sinai Medical CenterAdult Health (ELSA-Brasil) cohort
2022
Study protocol for the Innovative Support for Patients with SARS-COV-2 Infections Registry (INSPIRE): A longitudinal study of the medium and long-term sequelae of SARS-CoV-2 infection
O’Laughlin K, Thompson M, Hota B, Gottlieb M, Plumb ID, Chang AM, Wisk LE, Hall AJ, Wang RC, Spatz ES, Stephens KA, Huebinger RM, McDonald SA, Venkatesh A, Gentile N, Slovis BH, Hill M, Saydah S, Idris AH, Rodriguez R, Krumholz HM, Elmore JG, Weinstein RA, Nichol G, . Study protocol for the Innovative Support for Patients with SARS-COV-2 Infections Registry (INSPIRE): A longitudinal study of the medium and long-term sequelae of SARS-CoV-2 infection. PLOS ONE 2022, 17: e0264260. PMID: 35239680, PMCID: PMC8893622, DOI: 10.1371/journal.pone.0264260.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionLong-term sequelaePatient-reported outcomesRelative riskAcute SARS-CoV-2 infectionSARS-CoV-2 negative participantsHealth system encountersPredictors of sequelaeHealth recordsInstitutional review board approvalLongitudinal studyDigital health recordsReview board approvalSARS-CoV-2Secure online platformClinical outcomesStudy protocolNegative participantsViral testsSimilar symptomatologyNew diagnosisBoard approvalSequelaeSelf-administered surveyInfection
2020
Rates and Predictors of Patient Underreporting of Hospitalizations During Follow-Up After Acute Myocardial Infarction
Caraballo C, Khera R, Jones PG, Decker C, Schulz W, Spertus JA, Krumholz HM. Rates and Predictors of Patient Underreporting of Hospitalizations During Follow-Up After Acute Myocardial Infarction. Circulation Cardiovascular Quality And Outcomes 2020, 13: e006231. PMID: 32552061, PMCID: PMC9465954, DOI: 10.1161/circoutcomes.119.006231.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionMyocardial infarctionHospitalization eventsMedical recordsLongitudinal multicenter cohort studyMulticenter cohort studyMedical record abstractionDifferent patient characteristicsHealth care eventsPatients' underreportingTRIUMPH registryAccuracy of reportingCohort studyPatient characteristicsRecord abstractionProspective studyClinical studiesClinical investigationHospitalizationPatientsCare eventsInfarctionEvent ratesParticipantsPredictorsSex Differences in 1‐Year Health Status Following Percutaneous Coronary Intervention in Patients Without Acute Myocardial Infarction: Results From the China PEACE Prospective Study
Zheng X, Dreyer RP, Curtis JP, Liu S, Xu X, Bai X, Li X, Zhang H, Wang S, Masoudi FA, Spertus JA, Li J, Krumholz HM, Group F. Sex Differences in 1‐Year Health Status Following Percutaneous Coronary Intervention in Patients Without Acute Myocardial Infarction: Results From the China PEACE Prospective Study. Journal Of The American Heart Association 2020, 9: e014421. PMID: 32131687, PMCID: PMC7335522, DOI: 10.1161/jaha.119.014421.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionAcute myocardial infarctionSAQ Summary ScoreCoronary interventionHealth status outcomesMyocardial infarctionHealth statusSummary scoresSAQ qualityAngina frequencyStatus outcomesPercutaneous coronary intervention studiesSAQ angina frequency scoreAngina frequency scoreCoronary Intervention StudyMarginal clinical significanceSAQ angina frequencyCardiac risk factorsChinese tertiary hospitalBackground Sex differencesSex differencesMultivariable adjustmentDiabetes mellitusTertiary hospitalLife scores
2019
Patient-Reported Quality of Hospital Discharge Transitions: Results from the SILVER-AMI Study
Richards BG, Hajduk AM, Perry J, Krumholz HM, Khan AM, Chaudhry SI. Patient-Reported Quality of Hospital Discharge Transitions: Results from the SILVER-AMI Study. Journal Of General Internal Medicine 2019, 35: 808-814. PMID: 31654359, PMCID: PMC7080904, DOI: 10.1007/s11606-019-05414-8.Peer-Reviewed Original ResearchConceptsDays of dischargeEmergency department utilizationAcute myocardial infarctionPatient-reported qualityHospital discharge processOlder patientsAcute Myocardial Infarction StudyMyocardial Infarction StudyProspective cohort studyMedical record reviewEmergency room utilizationAdults age 75Key ResultsA totalHospital Consumer AssessmentSILVER-AMI StudyHospital discharge transitionsHigh-risk periodDesignMulti-centerCohort studyHospital dischargeMedian ageClinical outcomesRecord reviewAdverse outcomesResultsA totalAssociation Between Medication Adherence and 1‐Year Major Cardiovascular Adverse Events After Acute Myocardial Infarction in China
Shang P, Liu GG, Zheng X, Ho PM, Hu S, Li J, Jiang Z, Li X, Bai X, Gao Y, Xing C, Wang Y, Normand S, Krumholz HM. Association Between Medication Adherence and 1‐Year Major Cardiovascular Adverse Events After Acute Myocardial Infarction in China. Journal Of The American Heart Association 2019, 8: e011793. PMID: 31057004, PMCID: PMC6512098, DOI: 10.1161/jaha.118.011793.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionMedication adherencePoor adherenceGood adherenceAdverse eventsMyocardial infarctionGuideline-directed medical therapyMajor cardiovascular adverse eventsCardiovascular adverse eventsCardiovascular event riskLow education levelMore comorbiditiesCardiovascular eventsCardiovascular medicationsSecondary preventionCommon medicationsMedical therapyAMI outcomesAMI patientsCommon reasonCox modelLower riskMedicationsPatientsEvent risk
2018
Impact of 2017 ACC/AHA guidelines on prevalence of hypertension and eligibility for antihypertensive treatment in United States and China: nationally representative cross sectional study
Khera R, Lu Y, Lu J, Saxena A, Nasir K, Jiang L, Krumholz HM. Impact of 2017 ACC/AHA guidelines on prevalence of hypertension and eligibility for antihypertensive treatment in United States and China: nationally representative cross sectional study. The BMJ 2018, 362: k2357. PMID: 29997129, PMCID: PMC6039831, DOI: 10.1136/bmj.k2357.Peer-Reviewed Original ResearchConceptsACC/AHA guidelinesDiagnosis of hypertensionAge groupsHypertension guidelinesAHA guidelinesTreatment patternsCurrent guidelinesACC/AHA hypertension guidelinesHeart Association hypertension guidelinesCurrent treatment patternsIntensification of treatmentPrevalence of hypertensionNutrition Examination SurveyYears age groupUS National HealthYear old adultsSame age groupRetirement Longitudinal StudyAntihypertensive treatmentExamination SurveyNational HealthHypertensionAmerican CollegeChina HealthOlder adultsComparison of Prevalence, Awareness, Treatment, and Control of Cardiovascular Risk Factors in China and the United States
Lu Y, Wang P, Zhou T, Lu J, Spatz ES, Nasir K, Jiang L, Krumholz HM. Comparison of Prevalence, Awareness, Treatment, and Control of Cardiovascular Risk Factors in China and the United States. Journal Of The American Heart Association 2018, 7: e007462. PMID: 29374046, PMCID: PMC5850247, DOI: 10.1161/jaha.117.007462.Peer-Reviewed Original ResearchMeSH KeywordsAgedAntihypertensive AgentsAttitude of Health PersonnelBlood GlucoseBlood PressureBody Mass IndexCardiovascular DiseasesChinaDiabetes MellitusDyslipidemiasFemaleHealth Knowledge, Attitudes, PracticeHealth Status DisparitiesHumansHypertensionHypolipidemic AgentsLipidsLongitudinal StudiesMaleMiddle AgedNutrition SurveysObesityPractice Patterns, Physicians'PrevalencePrognosisRisk AssessmentRisk FactorsTime FactorsUnited StatesWaist CircumferenceConceptsHigher stroke prevalenceCardiovascular risk factorsHigh-sensitivity C-reactive proteinBody mass indexC-reactive proteinRisk factorsBlood pressureWaist circumferenceMass indexStroke prevalenceCardiovascular risk factor profileHigher mean blood pressureControl of hypertensionMean blood pressureBlood pressure levelsRisk factor profileComparison of prevalenceRepresentative population sampleLower ratesDyslipidemia awarenessSevere hypertensionHemoglobin A1cHypertension treatmentControl ratePlasma glucoseNational Trends in Nonstatin Use and Expenditures Among the US Adult Population From 2002 to 2013: Insights From Medical Expenditure Panel Survey
Salami JA, Warraich HJ, Valero‐Elizondo J, Spatz ES, Desai NR, Rana JS, Virani SS, Blankstein R, Khera A, Blaha MJ, Blumenthal RS, Katzen BT, Lloyd‐Jones D, Krumholz HM, Nasir K. National Trends in Nonstatin Use and Expenditures Among the US Adult Population From 2002 to 2013: Insights From Medical Expenditure Panel Survey. Journal Of The American Heart Association 2018, 7: e007132. PMID: 29358195, PMCID: PMC5850149, DOI: 10.1161/jaha.117.007132.Peer-Reviewed Original ResearchAdultAgedAtherosclerosisDatabases, FactualDrug CostsDrug PrescriptionsDyslipidemiasFemaleHealth Care SurveysHealth ExpendituresHealthcare DisparitiesHumansHydroxymethylglutaryl-CoA Reductase InhibitorsHypolipidemic AgentsLongitudinal StudiesMaleMedically UninsuredMiddle AgedPractice Patterns, Physicians'Racial GroupsRetrospective StudiesRisk FactorsSex FactorsSocioeconomic FactorsTime FactorsTreatment OutcomeUnited States
2016
Association Between Hospital Penalty Status Under the Hospital Readmission Reduction Program and Readmission Rates for Target and Nontarget Conditions
Desai NR, Ross JS, Kwon JY, Herrin J, Dharmarajan K, Bernheim SM, Krumholz HM, Horwitz LI. Association Between Hospital Penalty Status Under the Hospital Readmission Reduction Program and Readmission Rates for Target and Nontarget Conditions. JAMA 2016, 316: 2647-2656. PMID: 28027367, PMCID: PMC5599851, DOI: 10.1001/jama.2016.18533.Peer-Reviewed Original ResearchConceptsHospital Readmissions Reduction ProgramAcute myocardial infarctionReadmission ratesReadmissions Reduction ProgramHeart failurePenalty statusNontarget conditionsMedicare feeMean readmission rateThirty-day riskRetrospective cohort studyUnplanned readmission rateReduction programsHRRP announcementHRRP implementationPenalized hospitalsCohort studyService patientsMyocardial infarctionMAIN OUTCOMEExcess readmissionsMedicare beneficiariesService beneficiariesHospitalPatientsSlow Gait Speed and Risk of Mortality or Hospital Readmission After Myocardial Infarction in the Translational Research Investigating Underlying Disparities in Recovery from Acute Myocardial Infarction: Patients' Health Status Registry
Dodson JA, Arnold SV, Gosch KL, Gill TM, Spertus JA, Krumholz HM, Rich MW, Chaudhry SI, Forman DE, Masoudi FA, Alexander KP. Slow Gait Speed and Risk of Mortality or Hospital Readmission After Myocardial Infarction in the Translational Research Investigating Underlying Disparities in Recovery from Acute Myocardial Infarction: Patients' Health Status Registry. Journal Of The American Geriatrics Society 2016, 64: 596-601. PMID: 26926309, PMCID: PMC4803531, DOI: 10.1111/jgs.14016.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionMyocardial infarctionSlow gaitHospital readmissionGait speedOlder adultsCox proportional hazards regressionMarker of frailtySlow gait speedTranslational researchProportional hazards regressionOutcomes 1 yearRisk of mortalityAssessment 1 monthBaseline characteristicsObservational cohortClinical factorsDiabetes mellitusHeart failureHazards regressionPrognostic importancePrognostic valueHigh prevalenceInfarctionReadmission
2015
Gender Differences in the Trajectory of Recovery in Health Status Among Young Patients With Acute Myocardial Infarction
Dreyer RP, Wang Y, Strait KM, Lorenze NP, D'Onofrio G, Bueno H, Lichtman JH, Spertus JA, Krumholz HM. Gender Differences in the Trajectory of Recovery in Health Status Among Young Patients With Acute Myocardial Infarction. Circulation 2015, 131: 1971-1980. PMID: 25862743, PMCID: PMC4657729, DOI: 10.1161/circulationaha.114.014503.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionHealth status scoresHealth statusMyocardial infarctionStatus scoreMedical record abstractionMental summary scoresShort Form-12Disease-specific measuresHealth status measuresWomen's health statusYears of ageLower health status scoresLinear mixed-effects analysisPatients 18Younger patientsRecord abstractionForm-12Excess riskMixed-effects analysisPatient interviewsSpanish hospitalsBaseline hospitalizationSummary scoresGender differencesOrganizational culture change in U.S. hospitals: a mixed methods longitudinal intervention study
Curry LA, Linnander EL, Brewster AL, Ting H, Krumholz HM, Bradley EH. Organizational culture change in U.S. hospitals: a mixed methods longitudinal intervention study. Implementation Science 2015, 10: 29. PMID: 25889753, PMCID: PMC4356105, DOI: 10.1186/s13012-015-0218-0.Peer-Reviewed Original Research
2014
Sexual Activity and Counseling in the First Month After Acute Myocardial Infarction Among Younger Adults in the United States and Spain
Lindau ST, Abramsohn EM, Bueno H, D'Onofrio G, Lichtman JH, Lorenze NP, Mehta Sanghani R, Spatz ES, Spertus JA, Strait K, Wroblewski K, Zhou S, Krumholz HM. Sexual Activity and Counseling in the First Month After Acute Myocardial Infarction Among Younger Adults in the United States and Spain. Circulation 2014, 130: 2302-2309. PMID: 25512442, PMCID: PMC4322946, DOI: 10.1161/circulationaha.114.012709.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsCounselingFemaleHumansLongitudinal StudiesMaleMiddle AgedMyocardial InfarctionPhysician-Patient RelationsProspective StudiesRisk AssessmentSex FactorsSexual BehaviorSexual Dysfunction, PhysiologicalSexual Dysfunctions, PsychologicalSpainUnited StatesYoung AdultConceptsAcute myocardial infarctionSexual activityMyocardial infarctionPatient experienceYoung AMI Patients (VIRGO) studyBaseline sexual activityPhysicians counsel patientsRisk-adjusted analysisMen ages 18Sample of womenPhysician counselingCounsel patientsMedian ageSociety guidelinesFemale genderHeart rateSexual inactivityU.S. womenAge 18First monthPatientsYoung adultsPatient studiesCounselingWomenStrategies to reduce hospital 30-day risk-standardized mortality rates for patients with acute myocardial infarction: a cross-sectional and longitudinal survey
Bradley EH, Sipsma H, Brewster AL, Krumholz HM, Curry L. Strategies to reduce hospital 30-day risk-standardized mortality rates for patients with acute myocardial infarction: a cross-sectional and longitudinal survey. BMC Cardiovascular Disorders 2014, 14: 126. PMID: 25252826, PMCID: PMC4182840, DOI: 10.1186/1471-2261-14-126.Peer-Reviewed Original ResearchMeSH KeywordsCooperative BehaviorCross-Sectional StudiesEmergency Medical ServicesEmergency Medical TechniciansHealth Care SurveysHospital MortalityHospitalsHumansInservice TrainingInterdisciplinary CommunicationLongitudinal StudiesMedical Order Entry SystemsMyocardial InfarctionOrganizational CulturePatient Care TeamQuality ImprovementQuality Indicators, Health CareTime FactorsUnited StatesConceptsAcute myocardial infarctionAMI mortality ratesPercentage of hospitalsMortality rateMyocardial infarctionAMI mortalityHospital AMI mortality ratesRisk-standardized mortality ratesEmergency medical services (EMS) providersHospital strategiesCross-sectional surveyPhysician order entryBackgroundSurvival ratesAMI careMedical service providersResultsBetween 2010HospitalU.S. hospitalsOrder entryRegular trainingInfarctionLongitudinal analysisHospital performanceMortalityCurrent use
2013
Risk Factors for Hospital Admission Among Older Persons With Newly Diagnosed Heart Failure Findings From the Cardiovascular Health Study
Chaudhry SI, McAvay G, Chen S, Whitson H, Newman AB, Krumholz HM, Gill TM. Risk Factors for Hospital Admission Among Older Persons With Newly Diagnosed Heart Failure Findings From the Cardiovascular Health Study. Journal Of The American College Of Cardiology 2013, 61: 635-642. PMID: 23391194, PMCID: PMC3576871, DOI: 10.1016/j.jacc.2012.11.027.Peer-Reviewed Original ResearchConceptsHeart failure diagnosisIndependent risk factorHospital admissionCardiovascular Health StudyHeart failureGeriatric conditionsRisk factorsMuscle weaknessSlow gaitOlder personsHealth StudyNew diagnosisNew York Heart Association functional class IIICommunity-living older personsDepressed ejection fractionHeart Failure FindingsFunctional class IIIChronic kidney diseaseCause hospital admissionsMedical record reviewRelevant clinical dataLong-term riskDiabetes mellitusEjection fractionKidney disease
2011
Understanding the use and impact of the online community in a national quality improvement campaign
Nembhard IM, Nazem AG, Webster TR, Wang Y, Krumholz HM, Bradley EH. Understanding the use and impact of the online community in a national quality improvement campaign. BMJ Quality & Safety 2011, 20: 68. PMID: 21228078, DOI: 10.1136/bmjqs.2010.040253.Peer-Reviewed Original ResearchMeSH KeywordsHealth Care CoalitionsHospitals, CommunityHumansLongitudinal StudiesMaleOnline SystemsQuality ImprovementRegistriesUnited StatesConceptsOnline communitiesPerformance measurement issuesSilent usersNational Quality CampaignHeart attack careD2B AllianceMeasurement issuesQuality campaignOrganizationImprovement campaignInformation exchangeExpert guidanceRole changesQuality improvement campaignStaff useImpactHigh-volume usersAllianceCampaignPerformance improvementLack of associationData sourcesHospital SurveyHelpfulnessPerformance
2010
Applying Practice Recommendations for the Prevention and Treatment of Obesity in Children and Adolescents
Dorsey KB, Mauldon M, Magraw R, Valka J, Yu S, Krumholz HM. Applying Practice Recommendations for the Prevention and Treatment of Obesity in Children and Adolescents. Clinical Pediatrics 2010, 49: 137-145. PMID: 20080520, DOI: 10.1177/0009922809346567.Peer-Reviewed Original ResearchConceptsCross-sectional analysisObese patientsFifth visitDocumentation of BMIFirst clinic visitTreatment of obesityLongitudinal analysisIndividual risk behaviorsClinic visitsClinician adherenceMedical recordsWeight managementObesity preventionFirst visitClinicians' attentionRisk behaviorsPatientsPractice recommendationsVisitsOverweightBMIPreventionAdherenceTreatmentObesity
2009
National Efforts to Improve Door-to-Balloon Time Results From the Door-to-Balloon Alliance
Bradley EH, Nallamothu BK, Herrin J, Ting HH, Stern AF, Nembhard IM, Yuan CT, Green JC, Kline-Rogers E, Wang Y, Curtis JP, Webster TR, Masoudi FA, Fonarow GC, Brush JE, Krumholz HM. National Efforts to Improve Door-to-Balloon Time Results From the Door-to-Balloon Alliance. Journal Of The American College Of Cardiology 2009, 54: 2423-2429. PMID: 20082933, DOI: 10.1016/j.jacc.2009.11.003.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionD2B AllianceBalloon (D2B) AllianceHospital presentationD2B timeNational Cardiovascular Data Registry CathPCI RegistryPrimary percutaneous coronary interventionElevation myocardial infarctionPercutaneous coronary interventionLikelihood of patientsCathPCI RegistryCoronary interventionBalloon timeMyocardial infarctionAmerican CollegePatientsHospitalLongitudinal studyNational Quality CampaignOne-halfPresentationMinNational effortsInfarctionRegistryAttitudes, Training Experiences, and Professional Expectations of US General Surgery Residents: A National Survey
Yeo H, Viola K, Berg D, Lin Z, Nunez-Smith M, Cammann C, Bell RH, Sosa JA, Krumholz HM, Curry LA. Attitudes, Training Experiences, and Professional Expectations of US General Surgery Residents: A National Survey. JAMA 2009, 302: 1301-1308. PMID: 19773565, DOI: 10.1001/jama.2009.1386.Peer-Reviewed Original ResearchMeSH KeywordsAdultAttitude of Health PersonnelCareer ChoiceClinical CompetenceCross-Sectional StudiesEducation, Medical, GraduateFemaleGeneral SurgeryHumansInternship and ResidencyJob SatisfactionLongitudinal StudiesMaleProspective StudiesResearch DesignSex FactorsStudents, MedicalSurveys and QuestionnairesTime FactorsUnited StatesConceptsUS general surgery residentsGeneral surgery residentsSurgery residentsCross-sectional studyGeneral surgery residency programsCategorical general surgery residentsSurgery In-Training ExaminationResidency programsTraining yearSurgery residency programsSurgical residency programsPostgraduate year 2Postgraduate year 5In-Training ExaminationUnmet needYear 5Supportive peer relationshipsPrior yearSpecialty trainingNational surveyMost respondentsYear 2American BoardSources of strainPeer relationships