2023
Reclassification of moderate aortic stenosis based on data-driven phenotyping of hemodynamic progression
Cho I, Kim W, Kim S, Ko K, Seong Y, Kim D, Seo J, Shim C, Ha J, Mori M, Gupta A, You S, Hong G, Krumholz H. Reclassification of moderate aortic stenosis based on data-driven phenotyping of hemodynamic progression. Scientific Reports 2023, 13: 6694. PMID: 37095171, PMCID: PMC10125992, DOI: 10.1038/s41598-023-33683-1.Peer-Reviewed Original ResearchConceptsRapid progression groupModerate aortic stenosisAortic valve replacementSlow progression groupAortic stenosisProgression groupHemodynamic progressionRapid progressionMore rapid progressionLatent class trajectory modelingTransthoracic echocardiography studyBetween-group differencesData-driven phenotypingPressure gradient measurementAVR ratesModerate ASCause mortalityValve replacementEchocardiography studyAtrial fibrillationTTE studiesEchocardiographic dataRisk factorsPredictive valuePatients
2016
The Core Value of Cost-Effectiveness Analyses∗
Dhruva SS, Krumholz HM. The Core Value of Cost-Effectiveness Analyses∗. Journal Of The American College Of Cardiology 2016, 67: 39-41. PMID: 26764064, PMCID: PMC5459408, DOI: 10.1016/j.jacc.2015.11.013.Peer-Reviewed Original Research
2013
Trends in Aortic Valve Replacement for Elderly Patients in the United States, 1999-2011
Barreto-Filho JA, Wang Y, Dodson JA, Desai MM, Sugeng L, Geirsson A, Krumholz HM. Trends in Aortic Valve Replacement for Elderly Patients in the United States, 1999-2011. JAMA 2013, 310: 2078-2084. PMID: 24240935, PMCID: PMC4089974, DOI: 10.1001/jama.2013.282437.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAged, 80 and overAortic ValveBicuspid Aortic Valve DiseaseBlack PeopleCohort StudiesCoronary Artery BypassCross-Sectional StudiesFee-for-Service PlansFemaleHeart Defects, CongenitalHeart Valve DiseasesHeart Valve ProsthesisHeart Valve Prosthesis ImplantationHumansLength of StayMaleMedicarePatient ReadmissionTreatment OutcomeUnited StatesConceptsSurgical aortic valve replacementAortic valve replacementValve replacementProcedure ratesElderly patientsCoronary artery bypass graft surgeryArtery bypass graft surgeryCross-sectional cohort studyPatients 85 yearsBypass graft surgeryHigh mortality rateCause readmissionCABG surgeryGraft surgeryOlder patientsCohort studyReadmission ratesTranscatheter optionsBlack patientsTranscatheter treatmentMechanical prosthesesThirty-dayContemporary outcomesMAIN OUTCOMEMedicare fee
2004
Quality of life after aortic valve replacement with tissue and mechanical implants
Sedrakyan A, Hebert P, Vaccarino V, Paltiel AD, Elefteriades JA, Mattera J, Lin Z, Roumanis SA, Krumholz HM. Quality of life after aortic valve replacement with tissue and mechanical implants. Journal Of Thoracic And Cardiovascular Surgery 2004, 128: 266-272. PMID: 15282464, DOI: 10.1016/j.jtcvs.2003.12.014.Peer-Reviewed Original ResearchMeSH KeywordsAgedAortic ValveFemaleHeart Valve ProsthesisHumansMaleMiddle AgedProspective StudiesQuality of LifeConceptsAortic valve replacementQuality of lifeMechanical valve implantsMechanical valve recipientsValve replacementValve recipientsLife scoresValve implantsTissue valvesMechanical valvesMedical Outcomes Trust Short FormPopulation normsYale-New Haven HospitalMechanical valve replacementRate of complicationsUS population normsTissue valve replacementPrognostic factorsRole limitationsOnly significant differenceHealth SurveyAnalysis of covarianceBaseline qualityMean qualityPatients